2,3-di(1-pyrazolyl)-N-phenylmaleimide | 125849-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 2,3-di(1-pyrazolyl)-N-phenylmaleimide
• 英文别名: 1-Phenyl-3,4-bis(1H-pyrazol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione；1-phenyl-3,4-di(pyrazol-1-yl)pyrrole-2,5-dione
• CAS: 125849-45-8
• 化学式: C₁₆H₁₁N₅O₂
• 分子量: 305.296
• InChiKey: JADQLMVXMCBBGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吡唑 、 2,3-二氯-N-苯基马来酰亚胺 以 乙醇 为溶剂， 以16%的产率得到2,3-di(1-pyrazolyl)-N-phenylmaleimide
  参考文献：
  名称：

  Some synthetic applications of 2,3-Dichloro-N-phenylmaleimide: A novel synthesis of 2-phenylpyrrolo[3,4-b]quinoxaline-1,3-diones. I

  摘要：

  2,3-Dichloro-N-phenylmaleimide 2 undergoes nucleophilic substitution reactions by a variety of nucleophiles giving either monosubstituted 5 or disubstituted 3 products. Treatment of 5 with sodium azide at room temperature results in cyclization to the corresponding 2-phenylpyrrolo[3,4-b]quinoxaline-1,3-diones 6, while at higher temperatures 5 is reduced to the 2-amino-3-amino-N-phenylmaleimides 7. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00672-9

文献信息

• Katritzky, Alan R.; Fan, Wei-Qiang; Li, Qiao-Ling, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 885 - 892
  作者：Katritzky, Alan R.、Fan, Wei-Qiang、Li, Qiao-Ling、Bayyuk, Shibli

  DOI：——

  日期：——
• KATRIZKY, ALAN R.;FAN, WEI-QIANG;LI, QIAO-LING;BAYYUK, SHIBLI, J. HETEROCYCL. CHEM., 26,(1989) N, C. 885-892
  作者：KATRIZKY, ALAN R.、FAN, WEI-QIANG、LI, QIAO-LING、BAYYUK, SHIBLI

  DOI：——

  日期：——
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• Some synthetic applications of 2,3-Dichloro-N-phenylmaleimide: A novel synthesis of 2-phenylpyrrolo[3,4-b]quinoxaline-1,3-diones. I
  作者：Leila Hanaineh-Abdelnour、Shibly Bayyuk、Rima Theodorie

  DOI：10.1016/s0040-4020(99)00672-9

  日期：1999.10

  2,3-Dichloro-N-phenylmaleimide 2 undergoes nucleophilic substitution reactions by a variety of nucleophiles giving either monosubstituted 5 or disubstituted 3 products. Treatment of 5 with sodium azide at room temperature results in cyclization to the corresponding 2-phenylpyrrolo[3,4-b]quinoxaline-1,3-diones 6, while at higher temperatures 5 is reduced to the 2-amino-3-amino-N-phenylmaleimides 7. (C) 1999 Elsevier Science Ltd. All rights reserved.