5-(2-Trimethylsilylethynyl)pyridine-2-carboxylic acid | 1352713-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(2-Trimethylsilylethynyl)pyridine-2-carboxylic acid
• CAS: 1352713-12-2
• 化学式: C₁₁H₁₃NO₂Si
• 分子量: 219.315
• InChiKey: YZFGJZDJDBOQDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [iridium(III)(μ-chloro)(2-phenylpyridine)2]2 、 5-(2-Trimethylsilylethynyl)pyridine-2-carboxylic acid 在 silver triflate 、 Cs₂CO₃ 作用下， 以 丙酮 为溶剂， 以94%的产率得到[Ir(2-phenylpyridyl)2(OOCC5H3NCCSiMe3)]
  参考文献：
  名称：

  Elegant Approach to the Synthesis of a Unique Heteroleptic Cyclometalated Iridium(III)-Polyoxometalate Conjugate

  摘要：

  A novel heteroleptic cyclometalated iridium(III) complex with one picolinic acid derivative bearing a pendant terminal alkynyl tether has been prepared following a new synthetic route. This pendant alkynyl tether can be further engaged in palladium C-C coupling reactions, allowing its grafting to a Keggin-type polyoxometalate and thus providing a unique iridio-POM conjugate.

  DOI：

  10.1021/om200910p
• 作为产物：
  描述：

  5-溴-2-吡啶羧酸 、 三甲基乙炔基硅 在 正丙胺 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 作用下， 以52%的产率得到5-(2-Trimethylsilylethynyl)pyridine-2-carboxylic acid
  参考文献：
  名称：

  Elegant Approach to the Synthesis of a Unique Heteroleptic Cyclometalated Iridium(III)-Polyoxometalate Conjugate

  摘要：

  A novel heteroleptic cyclometalated iridium(III) complex with one picolinic acid derivative bearing a pendant terminal alkynyl tether has been prepared following a new synthetic route. This pendant alkynyl tether can be further engaged in palladium C-C coupling reactions, allowing its grafting to a Keggin-type polyoxometalate and thus providing a unique iridio-POM conjugate.

  DOI：

  10.1021/om200910p

文献信息

• Elegant Approach to the Synthesis of a Unique Heteroleptic Cyclometalated Iridium(III)-Polyoxometalate Conjugate
  作者：Benjamin Matt、Jamal Moussa、Lise-Marie Chamoreau、Carlos Afonso、Anna Proust、Hani Amouri、Guillaume Izzet

  DOI：10.1021/om200910p

  日期：2012.1.9

  A novel heteroleptic cyclometalated iridium(III) complex with one picolinic acid derivative bearing a pendant terminal alkynyl tether has been prepared following a new synthetic route. This pendant alkynyl tether can be further engaged in palladium C-C coupling reactions, allowing its grafting to a Keggin-type polyoxometalate and thus providing a unique iridio-POM conjugate.