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N-4,n-4-二乙基-2-甲基-1,4-苯二胺 | 148-71-0

中文名称
N-4,n-4-二乙基-2-甲基-1,4-苯二胺
中文别名
4-二乙胺基邻甲苯胺
英文名称
4-diethylamino-o-toluidine
英文别名
1,4-Benzenediamine, N4,N4-diethyl-2-methyl-;4-N,4-N-diethyl-2-methylbenzene-1,4-diamine
N-4,n-4-二乙基-2-甲基-1,4-苯二胺化学式
CAS
148-71-0
化学式
C11H18N2
mdl
MFCD00137576
分子量
178.277
InChiKey
XBTWVJKPQPQTDW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    300.3±22.0 °C(Predicted)
  • 密度:
    0.995±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.1
  • 重原子数:
    13
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.454
  • 拓扑面积:
    29.3
  • 氢给体数:
    1
  • 氢受体数:
    2

ADMET

毒理性
  • 副作用
职业性肝毒素 - 第二性肝毒素:在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

  • 危险等级:
    IRRITANT
  • 海关编码:
    2921590090

SDS

SDS:7a0a5bfffb91ed9aa572268d26360aff
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Name: 4-Amino-N N-Diethyl-m-Toluidine Hydrochloride 98% Material Safety Data Sheet
Synonym: None Known
CAS: 148-71-0
Section 1 - Chemical Product MSDS Name:4-Amino-N N-Diethyl-m-Toluidine Hydrochloride 98% Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
148-71-0 4-Amino-N,N-Diethyl-m-Toluidine Hydroc 98% 205-722-1
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Use only in a chemical fume hood. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 148-71-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: NH2C6H3(CH3)N(CH2CH3)2.HCl
Molecular Weight: 214.74

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 148-71-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Amino-N,N-Diethyl-m-Toluidine Hydrochloride - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 148-71-0: No information available.
Canada
CAS# 148-71-0 is listed on Canada's NDSL List.
CAS# 148-71-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 148-71-0 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    N-4,n-4-二乙基-2-甲基-1,4-苯二胺 在 potassium dichromate 、 aluminum(III) sulfate 、 sodium thiosulfate 、 zinc(II) chloride 作用下, 以 为溶剂, 反应 2.0h, 以19%的产率得到4-N,4-N-diethyl-2-hydroxysulfonothioyl-6-methylbenzene-1,4-diamine
    参考文献:
    名称:
    一系列吩噻嗪染料对病毒光灭活的影响因素
    摘要:
    之前测试了包括亚甲蓝 (MB) 在内的一系列四种吩噻嗪染料对红细胞悬浮液中病毒的光灭活能力。其中一种染料 1,9-二甲基-3-二甲氨基-7-二甲氨基吩噻嗪(1,9-二甲基亚甲基蓝)在对红细胞特性影响最小的条件下对几种 RNA 和 DNA 病毒表现出良好的细胞内和细胞外杀病毒活性。为了理解为什么 1, 9-二甲基亚甲基蓝的杀病毒特异性高于其他测试的吩噻嗪,将该染料的物理和化学性质与其他三个密切相关的类似物(MB、1,9-二甲基-3-二乙氨基-7-dl丁基氨基吩噻嗪 [化合物 4-140]、1,9-二甲基-3-二甲氨基-7-二乙氨基吩噻嗪 [化合物 6-136])。所有化合物的杀病毒活性都需要光和氧,并且单线态氧产率相对较高(>0.5),但 1,9-二甲基亚甲基蓝的单线态氧产率比 MB 高约 50%。此外,化合物的疏水性/亲水性各不相同,分配系数(2-辛醇:水)从 MB 的 0.11 到化合物
    DOI:
    10.1111/j.1751-1097.1998.tb05208.x
  • 作为产物:
    描述:
    二乙基-(3-甲基-4-亚硝基)-苯胺aluminum oxide 、 palladium/alumina 作用下, 80.0 ℃ 、10.3 MPa 条件下, 生成 N-4,n-4-二乙基-2-甲基-1,4-苯二胺
    参考文献:
    名称:
    US2811555
    摘要:
    公开号:
点击查看最新优质反应信息

文献信息

  • Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
    申请人:Vertex Pharmaceuticals Incorporated
    公开号:US20150231142A1
    公开(公告)日:2015-08-20
    The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
    本发明涉及含有上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物(A式、B式、C式或D式)的药物组合物。该发明还涉及这些药物配方,以及使用这些组合物治疗CFTR介导的疾病,特别是囊性纤维化的方法。
  • HAIR COLORING COMPOSITIONS
    申请人:——
    公开号:US20020032933A1
    公开(公告)日:2002-03-21
    A hair coloring composition comprising: (a) from about 0.0003 moles (per 100 g of composition) to less than about 0.09 moles (per 100 g of composition) of an inorganic peroxygen oxidizing agent; and (b) an oxidative hair coloring agent; wherein the pH of each of (a) and (b) is in the range of from about 1 to about 6 and wherein the combined mixture of (a) and (b) has a pH in the range of from about 1 to about 6. The products can provide excellent hair coloring and in-use efficacy benefits including excellent initial color and good wash fastness in combination with reduced hair damage at low pH.
    一种染发组合物,包括:(a)约0.0003摩尔(每100克组合物)至约0.09摩尔(每100克组合物)的无机过氧化氧化剂;和(b)氧化性染发剂;其中(a)和(b)的pH值在约1至约6的范围内,且(a)和(b)的混合物的pH值在约1至约6的范围内。该产品可以提供出色的染发效果和使用效果,包括出色的初始颜色和良好的耐洗性,同时在低pH值下减少头发损伤。
  • Hair colouring and conditioning compositions
    申请人:The Procter & Gamble Company
    公开号:US20030113286A1
    公开(公告)日:2003-06-19
    A hair colouring and conditioning composition comprising: (a) a hair colouring agent; and (b) a hair conditioning agent; wherein the composition provides an Average Combing Index Value of greater than 1.2 as measured by the Combing Technical Test Method. The products can provide excellent hair colouring together with excellent conditioning, reduced hair damage, brittleness and dryness, and is convenient and easy to use.
    一种包括: (a) 染发剂;和 (b) 护发剂; 的染发和护理组合物; 其中该组合物通过梳理技术测试方法测得的平均梳理指数值大于1.2。 该产品可以提供优秀的染发效果以及优秀的护理效果,减少头发损伤、脆弱和干燥,且使用方便。
  • Transition metal complexes as dye forming catalysts in hair coloring compositions
    申请人:Unilever Home & Personal Care USA, Division of Conopco, Inc.
    公开号:US20030066140A1
    公开(公告)日:2003-04-10
    A hair coloring composition comprising a first composition which comprises: (a) a dye forming transition metal salt or complex; which is first applied to the hair; and a second composition which comprises the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an aminophenol, a polyhydric phenol a catechol and mixtures thereof.
    一种染发组合物,包括以下两种组分: (a)染料形成的过渡金属盐或络合物;首先涂抹在头发上; 和包括以下两种组分的第二组合物,这两种组分在涂抹到头发之前混合: (a)包含水溶性过氧化氧化剂的组合物;和 (b)包含从芳香二胺、氨基酚、多羟基酚、邻苯二酚和它们的混合物中选择的一种或多种氧化染发剂的组合物。
  • Hair conditioning compositions and their use in hair colouring compositions
    申请人:The Procter & Gamble Company
    公开号:US20030219399A1
    公开(公告)日:2003-11-27
    The present invention relates to a hair care composition comprising a aminofunctional polysiloxane having a specified average effective particle size which provides improved durable conditioning particularly when utilised in conjunction with a hair colouring composition.
    本发明涉及一种头发护理组合物,包括具有特定平均有效粒径的氨基官能聚硅氧烷,当与染发组合物一起使用时,能提供改善的持久调理效果。
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