2-(3-trifluoromethylphenyl)benzyl alcohol | 773872-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-trifluoromethylphenyl)benzyl alcohol
• 英文别名: [2-[3-(Trifluoromethyl)phenyl]phenyl]methanol
• CAS: 773872-59-6
• 化学式: C₁₄H₁₁F₃O
• 分子量: 252.236
• InChiKey: OUEITMNHMOOZGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-trifluoromethylphenyl)benzyl alcohol 在 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以97%的产率得到2-(3-trifluoromethylphenyl)benzyl chloride
  参考文献：
  名称：

  Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation

  摘要：

  A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes; were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance was also demonstrated. On the basis of Hammett and KIE studies, the present reaction is proposed to proceed via a base-assisted deprotonative metalation pathway.

  DOI：

  10.1021/ol901854f
• 作为产物：
  描述：

  2-溴苄醇 、 3-(三氟甲基)苯硼酸 在 potassium fluoride 、 palladium diacetate 、 2-(二叔丁基膦)联苯 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以40%的产率得到2-(3-trifluoromethylphenyl)benzyl alcohol
  参考文献：
  名称：

  Highly Efficient and Versatile Synthesis of Polyarylfluorenes via Pd-Catalyzed C−H Bond Activation

  摘要：

  A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes; were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance was also demonstrated. On the basis of Hammett and KIE studies, the present reaction is proposed to proceed via a base-assisted deprotonative metalation pathway.

  DOI：

  10.1021/ol901854f

文献信息

• Distal-C–H Functionalization of Biphenyl Scaffolds Assisted by Easily Removable/Recyclable Aliphatic Nitrile Templates
  作者：Dasari Srinivas、Gedu Satyanarayana

  DOI：10.1021/acs.joc.3c02196

  日期：2024.1.5