methyl (2R)-2-(1,3-dioxoisoindol-2-yl)butanoate | 1242459-42-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2R)-2-(1,3-dioxoisoindol-2-yl)butanoate
• CAS: 1242459-42-2
• 化学式: C₁₃H₁₃NO₄
• 分子量: 247.251
• InChiKey: MROZWPVRAJLPNM-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.23
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.68
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butanoic acid 、 碘甲烷 在 silver(l) oxide 作用下， 生成 methyl (2R)-2-(1,3-dioxoisoindol-2-yl)butanoate
  参考文献：
  名称：

  Catalytic Asymmetric Protonation of α-Amino Acid-Derived Ketene Disilyl Acetals Using P-Spiro Diaminodioxaphosphonium Barfates as Chiral Proton

  摘要：

  Chiral diaminodioxaphosphonium salts have been developed and their unique abilities as a chiral proton have been revealed through the establishment of a highly enantioselective protonation of alpha-amino acid-derived ketene disilyl acetals.

  DOI：

  10.1021/ja105945z

文献信息

• Catalytic Asymmetric Protonation of α-Amino Acid-Derived Ketene Disilyl Acetals Using <i>P</i>-Spiro Diaminodioxaphosphonium Barfates as Chiral Proton
  作者：Daisuke Uraguchi、Natsuko Kinoshita、Takashi Ooi

  DOI：10.1021/ja105945z

  日期：2010.9.8

  Chiral diaminodioxaphosphonium salts have been developed and their unique abilities as a chiral proton have been revealed through the establishment of a highly enantioselective protonation of alpha-amino acid-derived ketene disilyl acetals.