4-(Benzo[1,3]dioxol-5-yloxy)-piperidine-1-carboxylic acid tert-butyl ester | 226398-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-(Benzo[1,3]dioxol-5-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-(1,3-benzodioxol-5-yloxy)piperidine-1-carboxylate
• CAS: 226398-06-7
• 化学式: C₁₇H₂₃NO₅
• 分子量: 321.373
• InChiKey: AHGHJWGLOCAJMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(Benzo[1,3]dioxol-5-yloxy)-piperidine-1-carboxylic acid tert-butyl ester 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成 4-(benzo[d][1,3]dioxol-5-yloxy)piperidine
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents

  摘要：

  A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with minimal effects on mean blood pressure in conscious rats. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.031
• 作为产物：
  描述：

  芝麻酚 、 N-Boc-4-羟基哌啶 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 4-(Benzo[1,3]dioxol-5-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents

  摘要：

  A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with minimal effects on mean blood pressure in conscious rats. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.031

文献信息

• Synthesis of aryl ethers from aminoalcohols using polymer-supported triphenylphosphine
  作者：Mike E. Lizarzaburu、Stephen J. Shuttleworth

  DOI：10.1016/s0040-4039(02)00222-8

  日期：2002.3

  Optimum conditions for the preparation of aryl-alkyl ethers from N-protected aminoalcohols using polymer-supported triphenylphosphine have been developed. In contrast to previous literature reports, it was discovered that the progress of this reaction is greatly improved when a tertiary amine base is employed, along with minor modifications being made to the order of reagent addition. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents
  作者：Hideki Kubota、Toshihiro Watanabe、Akio Kakefuda、Noriyuki Masuda、Kouichi Wada、Noe Ishii、Shuichi Sakamoto、Shin-ichi Tsukamoto

  DOI：10.1016/j.bmcl.2004.04.031

  日期：2004.6

  A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with minimal effects on mean blood pressure in conscious rats. (C) 2004 Elsevier Ltd. All rights reserved.