N-isopropylsuccinamide | 3026-11-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-isopropylsuccinamide
• 英文别名: Bernsteinsaeure-amid-isopropylamid；N-Isopropyl-succinamid；N'-propan-2-ylbutanediamide
• CAS: 3026-11-7
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: RXOMLHJELPQREP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(triethylstannyl)succinimide 、 异丙胺 以 甲醇 为溶剂， 反应 2.0h， 以100%的产率得到N-isopropylsuccinamide
  参考文献：
  名称：

  Shcherbakov, V. I.; Stolyarova, N. E.; D'yachkovskaya, O. S., Journal of general chemistry of the USSR, 1980, vol. 50, # 4, p. 714 - 718

  摘要：

  DOI：

文献信息

• Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
  申请人：Kuroita Takanobu

  公开号：US20100121048A1

  公开（公告）日：2010-05-13

  The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C 1-10 alkyl group optionally having substituent(s), a C 2-10 alkenyl group optionally having substituent(s), or a C 2-10 alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

  本发明涉及一种由式(I)表示的化合物：其中，环A是一种5或6成员的芳香杂环，可选地具有取代基；U、V和W分别独立地为C或N，但当U、V和W中的任何一个为N时，其他的应为C；Ra和Rb分别独立地为一个环状基团，可选地具有取代基；一个C1-10烷基，可选地具有取代基；一个C2-10烯基，可选地具有取代基；或一个C2-10炔基，可选地具有取代基；X是一条键或具有1到6个原子的主链间隔；Y是具有1到6个原子的主链间隔；Rc是一个含有杂原子作为构成原子的碳氢基团，可选地具有取代基；m和n分别独立地为1或2；环B可选地具有取代基，或其盐。本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压、高血压引起的各种器官损伤等的药物。
• Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
  申请人：PHENEX DISCOVERY VERWALTUNGS-GMBH

  公开号：US11078168B2

  公开（公告）日：2021-08-03

  The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof.

  本发明提供了吲哚胺 2,3-二氧化酶（IDO1）的调节剂及其在预防和/或治疗 IDO1 介导的疾病中的用途。具体而言，本发明提供了符合式（I）的化合物及其对映体、非对映体、同分异构体或药学上可接受的盐。
• Mizuno; Hirata, 1959, vol. 11, p. 241,243
  作者：Mizuno、Hirata

  DOI：——

  日期：——
• SHCHERBAKOV V. I.; STOLYAROVA N. E.; DYACHKOVSKAYA O. S.; KUZINA V. I., ZH. OBSHCH. XIMII, 1980, 50, HO 4, 886-891
  作者：SHCHERBAKOV V. I.、 STOLYAROVA N. E.、 DYACHKOVSKAYA O. S.、 KUZINA V. I.

  DOI：——

  日期：——
• SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE
  申请人：PHENEX DISCOVERY VERWALTUNGS-GMBH

  公开号：US20190292160A1

  公开（公告）日：2019-09-26

  The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof.