N,N-Dimethyl-norleucin | 5428-01-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-Dimethyl-norleucin
• 英文别名: N,N-dimethyl-norleucine；α-Dimethylamino-n-capronsaeure；4-Ethyl(dimethyl)ammonio-butanoate；2-(dimethylazaniumyl)hexanoate
• CAS: 5428-01-3
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: CXLSDGHWWXDHEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴己酸 、 二甲胺 生成 N,N-Dimethyl-norleucin
  参考文献：
  名称：

  Duvillier, Bulletin de la Societe Chimique de France, 1895, vol. <3> 13, p. 487

  摘要：

  DOI：

文献信息

• PHENYLQUINAZOLINE DERIVATIVES
  申请人：Eggenweiler Hans-Michael

  公开号：US20130178443A1

  公开（公告）日：2013-07-11

  Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in claim 1 , are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

  化合物(I)的新型喹唑啉酰胺衍生物，其中R1-R43和X具有权利要求书中指示的含义，是HSP90抑制剂，可用于制备用于治疗HSP90在疾病的抑制、调节和/或调控中发挥作用的药物。
• Compounds Useful as Immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US20150291549A1

  公开（公告）日：2015-10-15

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及一般用作免疫调节剂的化合物。提供的是包含这些化合物的化合物、组合物以及它们的使用方法。本公开还涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。
• Anti-ulcer composition
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0004686A2

  公开（公告）日：1979-10-17

  Zwitterionic surfactant compounds provide effective therapy for ulceration of the gastric mucosa. The tendency of . aspirin and other salicylate-based drugs to cause ulceration of the gastric mucosa is also reduced by administration of such drugs in conjunction with certain zwitterionic surfactants. The ammoniohexanoate zwitterionics are especially preferred in the management of both gastric and duodenal ulcers.

  表面活性剂是治疗胃粘膜溃疡的有效药物。将阿司匹林和其他水杨酸类药物与某些表面活性剂结合使用，也可减少此类药物导致胃黏膜溃疡的倾向。在治疗胃溃疡和十二指肠溃疡时，氨代己酸酯类表面活性剂尤其受到青睐。
• Liquid hand diswashing detergent
  申请人：CLARIANT INTERNATIONAL LTD.

  公开号：EP1365011A1

  公开（公告）日：2003-11-26

  The invention relates to a class of detergent compositions for use in hand dishwashing that provides excellent performance as measured by persistence of foam in the presence of oily and fatty types of soils. Testing based on escalating amounts of such soils to the extinction of the foam showed surprising advantage of hand dishwashing composition comprising at least two anionic surfactants and a polyethylene glycol and being essentially free of alkyl polyglucosides.

  本发明涉及一类用于手洗餐具的洗涤剂组合物，该组合物在油性和脂肪性污垢存在的情况下，以泡沫的持久性来衡量，具有优异的性能。测试表明，至少含有两种阴离子表面活性剂和一种聚乙二醇且基本上不含烷基多糖苷的手洗餐具组合物具有令人惊讶的优点。
• Cleaning, conditioning and styling hair care composition
  申请人：Stepan Company.

  公开号：US20010027171A1

  公开（公告）日：2001-10-04

  Disclosed are hair care compositions and methods for preparing such compositions which provide the benefits of cleaning, conditioning, curl retention, styling and setting properties simultaneously to hair in the application of a single product. The hair care compositions contain fatty alkyl amine salts, long chain quaternary ammonium salts and mixtures thereof of anionic styling polymers in a non-anionic surfactant system, wherein the surfactant system contains nonionic surfactants, semi-polar nonionic surfactants, amphoteric surfactants and mixtures thereof. The styling, setting and conditioning agents are present in the form of fatty alkyl amine salts or fatty quaternary ammonium salts which form anionic styling polymer particulate networks upon dilution in water. These networks are dispersed in the aqueous non-anionic surfactant system and are stabilized and thickened by optional swellable polymer thickening agents. Hair care compositions of the present invention can be made in the form of structured liquids, pearlescent/opaque isotropic liquid and/or translucent/clear isotropic liquids. The hair care compositions of the present invention, which allow for re-styling of the hair by wetting the hair with water, contain no anionic surfactants, silicones, solvents or cationic polymeric conditioning agents. Furthermore, multiple application of these hair care compositions does not produce a noticeable build-up on the hair.

  本发明公开了护发组合物和制备这种组合物的方法，这种组合物在使用单一产品时可同时为头发提供清洁、调理、卷曲保持、定型和定型等功效。护发组合物含有脂肪烷基胺盐、长链季铵盐及其混合物，它们是非阴离子表面活性剂体系中的阴离子定型聚合物，其中表面活性剂体系包含非离子表面活性剂、半极性非离子表面活性剂、两性表面活性剂及其混合物。定型剂、定型剂和调理剂以脂肪烷基胺盐或脂肪季铵盐的形式存在，在水中稀释后形成阴离子定型聚合物微粒网络。这些网络分散在水性非阴离子表面活性剂体系中，并通过任选的可膨胀聚合物增稠剂进行稳定和增稠。本发明的护发组合物可以结构液、珠光/不透明各向同性液体和/或半透明/透明各向同性液体的形式制成。本发明的护发组合物不含有阴离子表面活性剂、硅酮、溶剂或阳离子聚合物调理剂，只需用水润湿头发即可重新定型。此外，多次使用这些护发组合物不会在头发上产生明显的堆积。