(3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid cyclohexa-2,4-dienylmethyl ester | 372107-87-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid cyclohexa-2,4-dienylmethyl ester
• 英文别名: cyclohexa-2,4-dien-1-ylmethyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate
• CAS: 372107-87-4
• 化学式: C₁₈H₃₂N₂O₅
• 分子量: 356.462
• InChiKey: RXTGEHKPQZEYHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid cyclohexa-2,4-dienylmethyl ester 在 N,N'-二环己基碳二亚胺 作用下， 生成 N-[3-(2-{2-[3-(Cyclohexa-2,4-dienylmethoxycarbonylamino)-propoxy]-ethoxy}-ethoxy)-propyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  COVALENT MODIFICATION AND SURFACE IMMOBILIZATION OF NUCLEIC ACIDS VIA THE DIELS-ALDER BIOCONJUGATION METHOD

  摘要：

  The importance of chemically modified and surface immobilized nucleic acids has inspired the development of a wide variety of complementary techniques for covalent oligonucleotide preparation and immobilization. We are developing technology based on the use of a Diels-Alder reaction for accomplishing the covalent modification of oligonucleotides. Reported herein is preliminary progress toward the establishment of robust reagents for introducing the reactive functionality, as well as studies employing the BIACORE system to demonstrate surface immobilization by the method.

  DOI：

  10.1081/ncn-100002332
• 作为产物：
  描述：

  4,7,10-三氧-1,13-十三烷二胺 、 (2,4-Cyclohexadien-1-yl)methanol 、 N,N'-羰基二咪唑 生成 (3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propyl)-carbamic acid cyclohexa-2,4-dienylmethyl ester
  参考文献：
  名称：

  COVALENT MODIFICATION AND SURFACE IMMOBILIZATION OF NUCLEIC ACIDS VIA THE DIELS-ALDER BIOCONJUGATION METHOD

  摘要：

  The importance of chemically modified and surface immobilized nucleic acids has inspired the development of a wide variety of complementary techniques for covalent oligonucleotide preparation and immobilization. We are developing technology based on the use of a Diels-Alder reaction for accomplishing the covalent modification of oligonucleotides. Reported herein is preliminary progress toward the establishment of robust reagents for introducing the reactive functionality, as well as studies employing the BIACORE system to demonstrate surface immobilization by the method.

  DOI：

  10.1081/ncn-100002332

文献信息

• US7427678B2
  申请人：——

  公开号：US7427678B2

  公开（公告）日：2008-09-23