2-(2'-nitrophenyl)-4-(pyrid-2-yl)thiazole | 1262984-61-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2'-nitrophenyl)-4-(pyrid-2-yl)thiazole
• 英文别名: 2-[2-(2-Nitrophenyl)-4-thiazolyl]pyridine；2-(2-nitrophenyl)-4-pyridin-2-yl-1,3-thiazole
• CAS: 1262984-61-1
• 化学式: C₁₄H₉N₃O₂S
• 分子量: 283.31
• InChiKey: PUJHLCQZFMXTGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2'-nitrophenyl)-4-(pyrid-2-yl)thiazole 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以80%的产率得到2-(4-Pyridin-2-yl-1,3-thiazol-2-yl)aniline
  参考文献：
  名称：

  Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

  摘要：

  Anew thiazole sulfonamide (TIP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.10.055
• 作为产物：
  描述：

  2-(2-溴乙酰基)吡啶 、 2-nitrobenzothioamide 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以80%的产率得到2-(2'-nitrophenyl)-4-(pyrid-2-yl)thiazole
  参考文献：
  名称：

  Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

  摘要：

  Anew thiazole sulfonamide (TIP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.10.055

文献信息

• Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing
  作者：Aasif Helal、Sang Hyun Kim、Hong-Seok Kim

  DOI：10.1016/j.tet.2010.10.055

  日期：2010.12

  Anew thiazole sulfonamide (TIP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay. (C) 2010 Elsevier Ltd. All rights reserved.