(4-Chlorophenyl)(2-hydroxy-3-methylphenyl)methanone | 6279-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Chlorophenyl)(2-hydroxy-3-methylphenyl)methanone
• 英文别名: (4-chlorophenyl)-(2-hydroxy-3-methylphenyl)methanone
• CAS: 6279-04-5
• 化学式: C₁₄H₁₁ClO₂
• 分子量: 246.69
• InChiKey: RTAQNUUHINNFBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-Chlorophenyl)(2-hydroxy-3-methylphenyl)methanone 、 羟胺 以68%的产率得到
  参考文献：
  名称：

  SAUNDERS J. C.; WILLIAMSON W. R. N., J. MED. CHEM., 1979, 22, NO 12, 1554-1558

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[(E)-C-(4-chlorophenyl)-N-hydroxycarbonimidoyl]-6-methylphenol 以47%的产率得到
  参考文献：
  名称：

  SAUNDERS J. C.; WILLIAMSON W. R. N., J. MED. CHEM., 1979, 22, NO 12, 1554-1558

  摘要：

  DOI：
• 作为试剂：
  描述：

  三氯化铝 、 、 2-羟基-3-甲基苯甲酰氯 、 盐酸 、 乙醚 在 ice 、 碳酸氢钠 、 Sodium sulfate-III 、 乙醚 、 (4-Chlorophenyl)(2-hydroxy-3-methylphenyl)methanone 作用下， 以 氯苯 为溶剂， 反应 16.0h， 生成 (4-Chlorophenyl)(2-hydroxy-3-methylphenyl)methanone
  参考文献：
  名称：

  Anti-inflammatory 1,2-benzisoxazole derivatives

  摘要：

  具有抗炎活性的3-苯基取代的1,2-苯并异噁唑乙酸和丙酸衍生物。

  公开号：

  US03951999A1

文献信息

• 4-(M-benzoylphenyl)butyric acid derivatives
  申请人：Roussel-UCLAF

  公开号：US03931302A1

  公开（公告）日：1976-01-06

  Novel butyric acid derivatives of the formula ##SPC1## Wherein X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and -CH.sub.2 -CH - CH.sub.2 ##EQU1## wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X.sub.4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --OH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or organic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.

  化合物的式子为##SPC1##，其中X、X.sub.1、X.sub.2和X.sub.3分别选自氢、卤素、1-5个碳原子的低级烷基、1-5个碳原子的低级烷氧基、1-5个碳原子的低级烷基硫基、三氟甲氧基、三氟甲基硫基、三氟甲基、羟基和每个烷基的1-5个碳原子的双低级烷基氨基；R选自氢、1-5个碳原子的低级烷基、o-羧基苯基、2,3-二羟基丙基和-CH.sub.2-CH-CH.sub.2 ##EQU1##其中P和Q分别为1-5个碳原子的低级烷基，Z和X.sub.4分别选自氢和1-5个碳原子的低级烷基，Y选自氢和-OH，虚线表示当Y为氢时，R为氢或o-羧基苯基时，存在一个可选的双键。该化合物与非毒性药用可接受的矿物质或有机碱的盐具有抗炎和镇痛活性，并且基本上没有溃疡原性活性。该化合物的制备以及在其中形成的新中间体。
• Butyric acid derivatives for treating pain and inflammation
  申请人：Roussel-UCLAF

  公开号：US03995056A1

  公开（公告）日：1976-11-30

  Novel butyric acid derivatives of the formula ##SPC1## Wherein X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and ##EQU1## wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X.sub.4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --CH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or orgaic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.

  化合物的结构式为：##SPC1## 其中X，X.sub.1，X.sub.2和X.sub.3分别从氢，卤素，1至5个碳原子的低级烷基，1至5个碳原子的低级烷氧基，1至5个碳原子的低级烷硫基，三氟甲氧基，三氟甲基硫基，三氟甲基，OH和每个烷基的1至5个碳原子的二级烷胺中选择，而R从氢，1至5个碳原子的低级烷基，o-羧基苯基，2,3-二羟基丙基和##EQU1##中选择，其中P和Q分别是1至5个碳原子的低级烷基，Z和X.sub.4分别从氢和1至5个碳原子的低级烷基中选择，而Y从氢和--CH中选择，虚线表示当Y为氢时，当R为氢或o-羧基苯基时，存在一个可选的双键。这些化合物与无毒的药用矿物质或有机碱的盐具有抗炎和镇痛活性，并且基本上不具有溃疡原性活性，其制备和形成的新中间体。
• Ketone derivatives
  申请人：Lilly Industries Limited

  公开号：US04141995A1

  公开（公告）日：1979-02-27

  o-Hydroxybenzophenones and derivatives thereof are described together with a process for their production. The compounds have anti-allergy activity and are characterized by the presence of an alkyl substituent on the hydroxyphenyl ring.

  本文描述了o-羟基苯甲酮及其衍生物，以及它们的生产过程。这些化合物具有抗过敏活性，并以羟基苯环上存在烷基取代基为特征。
• EVANS, DELME;CRACKNELL, MARK E.;SAUNDERS, JOHN C.;SMITH, CHRISTINE E.;WIL+, J. MED. CHEM., 30,(1987) N 8, 1321-1327
  作者：EVANS, DELME、CRACKNELL, MARK E.、SAUNDERS, JOHN C.、SMITH, CHRISTINE E.、WIL+

  DOI：——

  日期：——
• US3931302A
  申请人：——

  公开号：US3931302A

  公开（公告）日：1976-01-06