N-(4-(benzo[d]oxazol-2-yl)phenyl)-4-methylbenzenesulfonamide | 42143-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-(benzo[d]oxazol-2-yl)phenyl)-4-methylbenzenesulfonamide
• 英文别名: N-(4-benzooxazol-2-yl-phenyl)-toluene-4-sulfonamide；N-[4-(1,3-Benzoxazol-2-YL)phenyl]-4-methylbenzene-1-sulfonamide；N-[4-(1,3-benzoxazol-2-yl)phenyl]-4-methylbenzenesulfonamide
• CAS: 42143-47-5
• 化学式: C₂₀H₁₆N₂O₃S
• mdl: MFCD01137508
• 分子量: 364.425
• InChiKey: OCVZUJDOHLMJJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(2-hydroxy-phenyl)-4-(toluene-4-sulfonylamino)-benzamide 反应 0.5h， 生成 N-(4-(benzo[d]oxazol-2-yl)phenyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  5-取代的2-（2-甲苯磺酰基氨基苯基）苯并恶唑的合成及光学性质

  摘要：

  DOI：

  10.1007/bf00471519

文献信息

• Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
  作者：Alex Washburn、Sanofar Abdeen、Yulia Ovechkina、Anne-Marie Ray、Mckayla Stevens、Siddhi Chitre、Jared Sivinski、Yangshin Park、James Johnson、Quyen Q. Hoang、Eli Chapman、Tanya Parish、Steven M. Johnson

  DOI：10.1016/j.bmcl.2019.04.034

  日期：2019.7

  Current treatments for Mycobacterium tuberculosis infections require long and complicated regimens that can lead to patient non-compliance, increasing incidences of antibiotic-resistant strains, and lack of efficacy against latent stages of disease. Thus, new therapeutics are needed to improve tuberculosis standard of care. One strategy is to target protein homeostasis pathways by inhibiting molecular chaperones such as GroEL/ES (HSP60/10) chaperonin systems. M. tuberculosis has two GroEL homologs: GroEL1 is not essential but is important for cytokine-dependent granuloma formation, while GroEL2 is essential for survival and likely functions as the canonical housekeeping chaperonin for folding proteins. Another strategy is to target the protein tyrosine phosphatase B (PtpB) virulence factor that M. tuberculosis secretes into host cells to help evade immune responses. In the present study, we have identified a series of GroEL/ES inhibitors that inhibit M. tuberculosis growth in liquid culture and biochemical function of PtpB in vitro. With further optimization, such dual-targeting GroEL/ES and PtpB inhibitors could be effective against all stages of tuberculosis - actively replicating bacteria, bacteria evading host cell immune responses, and granuloma formation in latent disease - which would be a significant advance to augment current therapeutics that primarily target actively replicating bacteria.
• Synthesis and optical properties of 5-substituted 2-(2-tosylaminophenyl)benzoxazoles
  作者：N. I. Chernova、M. V. Loseva、B. M. Bolotin、R. N. Nurmukhametov、Yu. S. Ryabokobylko

  DOI：10.1007/bf00471519

  日期：1973.4