quinidine; hydrobromide | 6363-60-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: quinidine; hydrobromide
• 英文别名: Chinidin; Hydrobromid；(9S)-6'-Methoxycinchonan-9-ol monohydrobromide；(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydrobromide
• CAS: 6363-60-6
• 化学式: BrH*C₂₀H₂₄N₂O₂
• 分子量: 405.335
• InChiKey: HDZGBIRSORQVNB-VJAUXQICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2909499000

文献信息

• [EN] PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE ACIDES AMINÉS GAMMA ET INTERMÉDIAIRES UTILISÉS DANS CE PROCÉDÉ
  申请人：ROYAL COLLEGE OF SURGEONS IE

  公开号：WO2013076225A1

  公开（公告）日：2013-05-30

  The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral centre. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.

  该发明涉及制备公式(I)的γ-氨基酸及其药学上可接受的盐、溶剂合物和前药，以及用于其制备的中间体。(公式I)其中R1选自烷基、烯基、炔基和环烷基，每种基团均可选择性地被取代，*表示一个手性中心。特别是，本发明提供了(S)-普瑞巴林的高效合成方法，适用于工业规模生产。
• PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS
  申请人：Royal College of Surgeons in Ireland

  公开号：US20140336412A1

  公开（公告）日：2014-11-13

  The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral centre. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.

  本发明涉及制备公式(I)的γ-氨基酸及其药学上可接受的盐、溶剂化物和前药，以及用于它们制备的中间体。(公式I)其中R1选自烷基、烯基、炔基和环烷基，每个基团均可选择性地被取代，*表示手性中心。特别地，本发明提供了一种适用于工业规模的(S)-pregabalin的高效合成方法。
• Skin penetration system for salts of amine-functional drugs
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0351897A2

  公开（公告）日：1990-01-24

  The invention involves pharmaceutical compositions for topical application comprising: (a) a pharmaceutically-acceptable salt of addition of an amine-functional drug (other than opioid analgesic drugs); (b) a C₇ to C₂₂ straight-chain or branched-chain, saturated or unsaturated, fatty acid having a melting point of less than about 50°C; and (c) a C₃-C₄ alkane diol.

  本发明涉及用于局部应用的药物组合物，包括 (a) 一种胺功能药物（阿片类镇痛药除外）的药学上可接受的加成盐； (b) C₇ 至 C₂₂ 直链或支链、饱和或不饱和脂肪酸，熔点低于约 50°C；以及 (c) C₃-C₄ 烷二醇。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：M. Technique Co., Ltd.

  公开号：EP3318543A1

  公开（公告）日：2018-05-09

  The present invention addresses the problem of providing a method for producing an organic compound by a phase transfer catalysis reaction using a forced thin-film microreactor. In the present invention, at least two types of fluid, which are a first fluid and a second fluid are used; the first fluid and the second fluid are not miscible with each other; at least the first fluid thereamong includes one or two items selected from the three items of an organic compound, a reactant, and a phase transfer catalyst; from among the fluids other than the first fluid, at least the second fluid includes at least one item from among the items not selected from the three items; the overall first fluid and second fluid contain all of the three items; and each of the fluids meraged

  本发明要解决的问题是提供一种利用强制薄膜微反应器通过相转移催化反应生产有机化合物的方法。在本发明中，至少使用了两种流体，即第一流体和第二流体；第一流体和第二流体互不相溶；至少第一流体中包括从有机化合物、反应物和相转移催化剂三者中选出的一个或两个项目；在除第一流体以外的流体中，至少第二流体包括从未曾从三者中选出的项目中选出的至少一个项目；第一流体和第二流体总体上包含三者中的所有项目；并且每种流体都合并了
• Method for producing an organic compound in a rotating forced thin-film microreactor
  申请人：M. TECHNIQUE CO., LTD.

  公开号：US10287232B2

  公开（公告）日：2019-05-14

  At least a first fluid and a second fluid are used and are not miscible with each other. At least the first fluid includes one or two items selected from an organic compound, a reactant, and a phase transfer catalyst. From among the fluids other than the first fluid, at least the second fluid includes at least one item from among the items not selected from the three items. The first fluid and second fluid contain all three items. Each of the fluids are merged in a thin-film fluid formed between processing faces that rotate relative to each other. A phase transfer catalyst reaction occurs in the thin-film fluid. Among the first fluid and the second fluid, at least the fluid containing the phase transfer catalyst is prepared so that the phase transfer catalyst is substantially homogeneously mixed before being introduced between the processing faces.

  至少使用第一种流体和第二种流体，这两种流体互不相溶。至少第一种流体包括一种或两种选自有机化合物、反应物和相转移催化剂的物质。在除第一种流体之外的其他流体中，至少第二种流体包括至少一种未从上述三种流体中选出的物质。第一种流体和第二种流体包含所有三种物质。每种流体在相对旋转的加工面之间形成的薄膜流体中合并。薄膜流体中发生相转移催化剂反应。在第一种流体和第二种流体中，至少含有相转移催化剂的流体是经过制备的，以便在将相转移催化剂引入加工面之间之前使其基本均匀混合。