5,6-Dichloro-1-cyclopentyl-2-methylbenzimidazole | 1360442-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5,6-Dichloro-1-cyclopentyl-2-methylbenzimidazole
• CAS: 1360442-71-2
• 化学式: C₁₃H₁₄Cl₂N₂
• 分子量: 269.174
• InChiKey: XKFCABYIFKGDPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5,6-二氯-2-甲基苯并咪唑 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 5,6-Dichloro-1-cyclopentyl-2-methylbenzimidazole
  参考文献：
  名称：

  Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

  摘要：

  We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.088

文献信息

• Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents
  作者：Hamad M. Alkahtani、Abdullahi Y. Abbas、Shudong Wang

  DOI：10.1016/j.bmcl.2011.12.088

  日期：2012.2

  We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis. (C) 2011 Elsevier Ltd. All rights reserved.