N-[1-(4-甲氧基苯基)-2-甲基丙-2-基]乙酰胺 | 926319-54-2

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[1-(4-甲氧基苯基)-2-甲基丙-2-基]乙酰胺
• 英文名称: N-[1-(4-methoxyphenyl)-2-methylpropan-2-yl]acetamide
• CAS: 926319-54-2
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.29
• InChiKey: DDQHQQRZYRDMQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA FABRICATION DE R-6-HYDROXY-8-[1-HYDROXY-2-[2- (4-MÉTHOXYPHÉNYL)-1,1-DIMÉTHYLÉTHYLAMINOÉTHYL]-2H-1,4-BENZOXAZIN-3 (4H)-ONE CHLORHYDRATE
  申请人：LESVI LABORATORIOS SL

  公开号：WO2018114887A1

  公开（公告）日：2018-06-28

  The present invention provides an improved process for the manufacture (R)-6- hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4- benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2- (4-methoxyphenyl)ethyl amine L-tartrate salt, 1,1-dimethyl-2-(4-methoxyphenyl)ethyl amine maletate salt or the camphorsulfonate salt of intermediate (4). The invention also relates to sais salts, to processes for preparing them and to their use for the manufacture of (R)-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl- ethylamino-ethyl]-2H-1,4-benzoxazin-3(4H)-one or a pharmaceutically acceptable salt thereof.

  本发明提供了一种改进的制造(R)-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1,1-二甲基乙基氨基]乙基]-2H-1,4-苯并噁嗪-3(4H)-酮的工艺，通过使用1,1-二甲基-2-(4-甲氧基苯基)乙基胺L-酒石酸盐，1,1-二甲基-2-(4-甲氧基苯基)乙基胺马来酸盐或中间体(4)的樟脑磺酸盐，以高纯度和高产率制备该化合物。本发明还涉及这些盐的制备工艺及其用于制备(R)-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1,1-二甲基乙基氨基]乙基]-2H-1,4-苯并噁嗪-3(4H)-酮或其药学上可接受的盐的用途。
• Process for the manufacture of R-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride
  申请人：INKE, S.A.

  公开号：US10800748B2

  公开（公告）日：2020-10-13

  The present invention provides an improved process for the manufacture (R)-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4-benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2-(4-methoxyphenyl)ethyl amine L-tartrate salt, 1,1-dimethyl-2-(4-methoxyphenyl)ethyl amine maletate salt or the camphorsulfonate salt of intermediate (4). The invention also relates to said salts, to processes for preparing them and to their use for the manufacture of (R)-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4-benzoxazin-3(4H)-one or a pharmaceutically acceptable salt thereof.

  本发明提供了一种高纯度、高收率生产(R)-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1,1-二甲基-乙基氨基-乙基]-2H-1,4-苯并恶嗪-3(4H)-酮的改进工艺、通过使用中间体 (4) 的 1,1-二甲基-2-(4-甲氧基苯基)乙胺 L-酒石酸盐、1,1-二甲基-2-(4-甲氧基苯基)乙胺苹果酸盐或樟脑磺酸盐。本发明还涉及上述盐类、制备它们的工艺及其用于制造(R)-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1,1-二甲基-乙基氨基-乙基]-2H-1,4-苯并恶嗪-3(4H)-酮或其药学上可接受的盐。
• VERFAHREN ZUR HERSTELLUNG VON BETAMIMETIKA
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：EP1917253B1

  公开（公告）日：2015-01-07
• IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE
  申请人：INKE, S.A.

  公开号：EP3558954B1

  公开（公告）日：2021-11-03