N-cyclopropyl-3-methylbutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclopropyl-3-methylbutanamide
• 化学式: C₈H₁₅NO
• mdl: MFCD01338057
• 分子量: 141.21
• InChiKey: BRPWLZJXBXTZKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
  申请人：Gruenenthal GmbH

  公开号：US20170197971A1

  公开（公告）日：2017-07-13

  The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

  本发明涉及3-(羧甲基)-8-氨基-2-氧代-1,3-二氮杂螺[4.5]癸烷衍生物，它们的制备方法以及它们在医学中的应用，特别是在疼痛治疗中的应用。
• [EN] 2-(BENZOTHIAZOL-2-YL)-2-CYANO-ACETAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIAL LIPASE INHIBITORS<br/>[FR] DÉRIVÉS DE 2-(BENZOTHIAZOL-2-YL)-2-CYANO-ACÉTAMIDE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA LIPASE ENDOTHÉLIALE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017214005A1

  公开（公告）日：2017-12-14

  The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.

  本发明提供了以下式（I）的化合物：如规范中定义的，并包括任何这种新型化合物的组合物。这些化合物是内皮脂酶抑制剂，可用作药物。
• ALPHA-(N-SULFONAMIDO)ACETAMIDE DERIVATIVES AS BETA-AMYLOID INHIBITORS
  申请人：Parker F. Michael

  公开号：US20080085894A1

  公开（公告）日：2008-04-10

  There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R 1 , R 2 and R 3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.

  提供了一系列新型α-(N-磺酰胺基)乙酰胺化合物的公式(I)，其中R、R1、R2和R3在此定义，它们是β-淀粉样肽（β-AP）产生的抑制剂，并且在治疗阿尔茨海默病和其他受到抗淀粉样蛋白活性影响的疾病中有用。
• BENZIMIDAZOLE RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
  申请人：Cooymans Ludwig Paul

  公开号：US20130267508A1

  公开（公告）日：2013-10-10

  Benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

  若干苯并咪唑化合物具有抑制RSV复制的活性，其化学式为，其前药、N-氧化物、加合盐、季铵盐、金属配合物及其立体化学异构体形式，含有这些化合物作为活性成分的组合物以及制备这些化合物和组合物的方法。
• SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Edmondson Scott

  公开号：US20140057893A1

  公开（公告）日：2014-02-27

  Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  公开了式I的替代环丙基化合物及其药学上可接受的盐，作为治疗或预防2型糖尿病和类似疾病的有用药物。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。