N,N'-Bis-(4-carbamimidoyl-phenyl)-terephthalamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT | 5507-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-(4-carbamimidoyl-phenyl)-terephthalamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT
• 英文别名: N~1~,N~4~-Bis(4-carbamimidoylphenyl)benzene-1,4-dicarboxamide--hydrogen chloride (1/1)；1-N,4-N-bis(4-carbamimidoylphenyl)benzene-1,4-dicarboxamide;hydrochloride
• CAS: 5507-13-1
• 化学式: C₂₂H₂₀N₆O₂*2ClH
• 分子量: 473.362
• InChiKey: VUUCSNRTTFCNFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.18
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  158
• 氢给体数：
  7
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对苯二甲酰氯 、 4-aminobenzamidine dihydrochloride 在 吡啶 作用下， 以 1,4-二氧六环 为溶剂， 生成 N,N'-Bis-(4-carbamimidoyl-phenyl)-terephthalamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

  摘要：

  A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.034

文献信息

• Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
  作者：Jean Jacques Vanden Eynde、Annie Mayence、Tien L Huang、Margaret S Collins、Sandra Rebholz、Peter D Walzer、Melanie T Cushion

  DOI：10.1016/j.bmcl.2004.06.034

  日期：2004.9

  A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study. (C) 2004 Elsevier Ltd. All rights reserved.