N-[2-(1,4-二甲氧基萘-2-基)乙基]三氟乙酰胺 | 1037294-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-[2-(1,4-二甲氧基萘-2-基)乙基]三氟乙酰胺
• 英文名称: N-[2-(1,4-dimethoxynaphth-2-yl)ethyl]trifluoroacetamide
• 英文别名: N-[2-(1,4-dimethoxynaphthalen-2-yl)ethyl]-2,2,2-trifluoroacetamide
• CAS: 1037294-85-1
• 化学式: C₁₆H₁₆F₃NO₃
• 分子量: 327.303
• InChiKey: YVLBFJZHXPDPMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 N-[2-(1,4-二甲氧基萘-2-基)乙基]三氟乙酰胺 在 氢溴酸 、 溶剂黄146 作用下， 反应 8.0h， 以54%的产率得到N-[2-(3-(溴甲基)-1,4-二甲氧基萘-2-基)乙基]三氟乙酰胺
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014
• 作为产物：
  描述：

  三氟乙酸乙酯 、 (dimethoxy-1,4 naphtyl-2)-2 ethylamine 以 四氢呋喃 为溶剂， 反应 4.0h， 以99%的产率得到N-[2-(1,4-二甲氧基萘-2-基)乙基]三氟乙酰胺
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014

文献信息

• Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones
  作者：Jan Jacobs、Jurgen Deblander、Bart Kesteleyn、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/j.tet.2008.03.014

  日期：2008.5

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.