(dimethoxy-1,4 naphtyl-2)-2 ethylamine | 207740-21-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (dimethoxy-1,4 naphtyl-2)-2 ethylamine
• 英文别名: 2-(1,4-dimethoxynaphth-2-yl)ethylamine；2-(1,4-Dimethoxy-2-naphthalenyl)ethylamine；2-(1,4-dimethoxynaphthalen-2-yl)ethanamine
• CAS: 207740-21-4
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: VKWQEEWEGKDTDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (dimethoxy-1,4 naphtyl-2)-2 ethylamine 在 magnesium sulfate 、 potassium iodide 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 7.5h， 生成 2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline
  参考文献：
  名称：

  Synthesis of 1-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  首次通过活化的Pictet–Spengler反应合成了1,2-取代的1,2,3,4-四氢苯[g]异喹啉-5,10-二酮，该反应使用了2-(1,4-二甲氧基萘-2-基)乙胺的相应亚胺，在酰氯和AlCl3的存在下进行，随后在硝酸中用银(II)氧化物进行氧化。根据反应条件，N-三氯乙酰保护基团可以被切除，转化为N-甲氧基羧酸基团，或转变为N-(2-氧基乙酰酰胺)结构。合成的1,2-取代的1,2,3,4-四氢苯[g]异喹啉-5,10-二酮构成了一类新的醌，尚未有文献报道。

  DOI：

  10.1039/c0ob00391c
• 作为产物：
  描述：

  2-(cyanomethyl)-1,4-dimethoxynaphthalene 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以74%的产率得到(dimethoxy-1,4 naphtyl-2)-2 ethylamine
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014

文献信息

• DEUTERIUM FREE, STABLE ISOTOPE LABELED 2-PHENYLETHYLAMINE HALLUCINOGENS AND/OR STIMULANTS, METHODS OF THEIR PREPARATION AND THEIR USE
  申请人：Johansen Jon Eigill

  公开号：US20140227792A1

  公开（公告）日：2014-08-14

  Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.

  不含氘的、稳定同位素标记的致幻剂和/或兴奋剂，含有基于2-苯乙胺的结构单元，并且至少含有来自13C、15N和18O组成的稳定同位素中的三种作为自由碱和其盐的方法；它们的制备方法及其在化学分析中的使用，特别是在法医化学分析和代谢研究中的应用。
• TEST KIT FOR THE QUANTITATIVE DETERMINATION OF NARCOTIC DRUGS
  申请人：CHIRON AS

  公开号：US20150204893A1

  公开（公告）日：2015-07-23

  A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein the isotopologue differs from vessel to vessel and—wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.

  一种用于定量测定麻醉药物的检测试剂盒，包括（A）一系列密封容器，每个容器中含有一种去氘同位素麻醉药物，其浓度和数量均被精确定义，其中同位素从容器到容器不同，同位素的数量在容器到容器之间不同或对所有容器都相同；和/或（B）一系列密封容器，每个容器中含有相同的同位素，其浓度和数量被精确定义，数量在容器到容器之间不同；其中自由同位素选自麻醉药物、前药、盐、溶剂、水合物和多晶形，并且在分子中至少包含三种稳定同位素，所述稳定同位素选自13C、15N和18O，其标记度至少为95摩尔％；使用该检测试剂盒和一种定量测定麻醉药物的方法。
• [EN] PHENALKYLAMINES AND METHODS OF TREATING MOOD DISORDERS<br/>[FR] PHÉNALKYLAMINES ET PROCÉDÉS DE TRAITEMENT DE TROUBLES DE L'HUMEUR
  申请人：GILGAMESH PHARMACEUTICALS INC

  公开号：WO2022006186A1

  公开（公告）日：2022-01-06

  Phenalkylamines and methods of treating mood disorders with phenalkylamines. Also provided are pharmaceutical compositions that include phenalkylamines.

  Phenalkylamines和使用Phenalkylamines治疗情绪障碍的方法。还提供了包含Phenalkylamines的制药组合物。
• Deuterium free, stable isotope labeled 2-phenylethylamine hallucinogens and/or stimulants, methods fo their preparation and their use
  申请人：Chiron AS

  公开号：EP2551675A1

  公开（公告）日：2013-01-30

  Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of 13C, 15N and 18O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.

  不含氘的稳定同位素标记致幻剂和/或兴奋剂，含有一个以 2-苯基乙胺为基础的结构单元，并含有至少三个从 13C、15N 和 18O 组成的组中选出的稳定同位素作为游离碱及其盐；其制备方法及其在化学分析（特别是法医化学分析）和新陈代谢研究中的用途。
• Test kit for the quantitative determination of narcotic drugs
  申请人：Chiron AS

  公开号：EP2687854A1

  公开（公告）日：2014-01-22

  A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, - wherein the isotopologue differs from vessel to vessel and - wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; - wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13C, 15N and 18O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.

  用于定量测定麻醉药品的试剂盒，包括 (A) 一系列密封容器，每个容器装有浓度和数量完全确定的麻醉药品的无 氘同位素、 - 其中各容器的同位素不同，并且 - 其中同位素的数量因容器而异或所有容器相同；和/或 (B) 一系列密封容器，每个容器以完全确定的浓度和数量含有相同的同位 素，其数量因容器而异； - 其中游离的同位素选自麻醉药品；原药、盐、溶液、水合物和多晶型物，以及 分子中至少含有三个稳定同位素，选自 13C、15N 和 18O 组成的组，标记度至少为 95 摩尔-%； 使用检测试剂盒和方法定量测定麻醉药品。