3-[(4-Phenylmethoxyphenyl)methylamino]azepan-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(4-Phenylmethoxyphenyl)methylamino]azepan-2-one
• 化学式: C₂₀H₂₄N₂O₂
• mdl: MFCD01475344
• 分子量: 324.4
• InChiKey: ITZXKOVEGUBANW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 3-aminopyrrolidone derivatives
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1533298A1

  公开（公告）日：2005-05-25

  This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I)    wherein mis an integer from 1 to 3 Xis methylene, oxygen, sulphur or a NR6 group; R1is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5, R6are independently hydrogen or C1-C6 alkyl;    and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

  这项发明涉及化合物和使用3-氨基吡咯烷酮衍生物和类似物的以下通用式(I)： 其中m是1到3的整数，X是亚甲基、氧、硫或NR6基团；R1是直链或支链的C1-C8烷基或C3-C8烯基或C3-C8炔基链，可选择地取代为CF3、苯基、苯氧基或萘基，芳香环可选择地取代为一个或多个C1-C4烷基、卤素、三氟甲基、羟基或C1-C4烷氧基基团；R2、R3独立地是氢、C1-C3烷基链、卤素、三氟甲基、羟基或C1-C4烷氧基基团；R4、R5、R6独立地是氢或C1-C6烷基；以及其药用盐，作为钠和/或钙通道调节剂活性，因此在预防、缓解和治疗广泛范围的病理，包括但不限于神经、精神、心血管、炎症性、眼科、泌尿、代谢和胃肠疾病方面有用，上述机制已被描述为起病理作用。
• 3-Aminopyrrolidone derivatives
  申请人：Thaler Florian

  公开号：US20070135410A1

  公开（公告）日：2007-06-14

  3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases.

  3-氨基吡咯烷酮化合物及其药学上可接受的盐，作为钠和/或钙通道调节剂具有活性，因此可用于预防、缓解和治愈广泛的病理状况，包括但不限于心血管、炎症、眼科、泌尿学、代谢和胃肠疾病。
• 3-AMINOPYRROLIDONE DERIVATIVES
  申请人：THALER Florian

  公开号：US20100048665A1

  公开（公告）日：2010-02-25

  3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases.

  3-氨基吡咯烷酮化合物及其药学上可接受的盐，可以作为钠和/或钙通道调节剂而发挥作用，因此在预防、缓解和治愈广泛的病理状况方面有用，包括但不限于心血管、炎症、眼科、泌尿学、代谢和胃肠疾病。
• JP2007511564A
  申请人：——

  公开号：JP2007511564A

  公开（公告）日：2007-05-10
• US7968592B2
  申请人：——

  公开号：US7968592B2

  公开（公告）日：2011-06-28