N-acetyl-N-allylglycine | 222725-34-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-N-allylglycine
• 英文别名: 2-[N-(prop-2-en-1-yl)acetamido]acetic acid；2-[acetyl(prop-2-enyl)amino]acetic acid
• CAS: 222725-34-0
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: AZQRPWIMBWINGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetyl-N-allylglycine 、 N-allylglycyl-phenylalanine methyl ester 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 生成 N-acetyl-N-allylglycyl-N-allylglycylphenylalanine methyl ester
  参考文献：
  名称：

  Fmoc-N-allyl Glycine Derived N-allyl-2,5-Diketopiperazines

  摘要：

  The title compound was prepared from chloroacetic acid and elongated to dipeptides, which cyclized spontaneously upon Fmoc-deprotection to form N-allylated 2,5-diketopiperazines.

  DOI：

  10.1080/00397919908086067
• 作为产物：
  描述：

  烯丙基氨基乙酸盐酸盐 、 乙酸酐 在 吡啶 作用下， 反应 3.0h， 以71%的产率得到N-acetyl-N-allylglycine
  参考文献：
  名称：

  Fmoc-N-allyl Glycine Derived N-allyl-2,5-Diketopiperazines

  摘要：

  The title compound was prepared from chloroacetic acid and elongated to dipeptides, which cyclized spontaneously upon Fmoc-deprotection to form N-allylated 2,5-diketopiperazines.

  DOI：

  10.1080/00397919908086067

文献信息

• Synthesis of macrocyclic analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE)
  作者：Paul W. R. Harris、Margaret A. Brimble

  DOI：10.1039/b605293b

  日期：——

  The syntheses of seven macrocyclic analogues of the neuroprotective tripeptide glycyl-L-prolyl-L-glutamic acid (GPE) 1 are described. Macrocycles 6 and 7 mimic the cis conformer of GPE whereas macrocycles 2–5, 8, and 9 mimic the trans conformer of GPE. The macrocyclic peptides of well-defined geometry were prepared via Grubbs ring closing metathesis of an appropriate diene precursor. In turn each of the diene precursors were prepared from the readily available allyl-substituted amino acid building blocks 12, 13, 14, 27, 36 and 51.

  描述了七种神经保护三肽甘氨酸-L-脯氨酸-L-谷氨酸（GPE）1的宏环类似物。宏环6和7模仿GPE的顺式构象，而宏环2-5、8和9则模仿GPE的反式构象。具有明确几何形状的宏环肽是通过Grubbs环闭合反应从适当的二烯前体合成的。反过来，每个二烯前体是由易得的烯丙基取代氨基酸构建单元12、13、14、27、36和51合成的。
• [EN] AN ENANTIOSELECTIVE PROCESS FOR THE SYNTHESIS OF (2S,4R)-4-HYDROXYPIPECOLIC ACID<br/>[FR] PROCÉDÉ ÉNANTIOSÉLECTIF DE SYNTHÈSE D'ACIDE (2S,4R)-4-HYDROXYPIPÉCOLIQUE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2016120890A1

  公开（公告）日：2016-08-04

  The present invention relates to an improved process for synthesis of 4-hydroxy pipecolic acid. The present invention relates to an improved enantioselective process for the synthesis of (2S,4R)-4-hydroxypipecolic acid via Co(III) (salen)-catalyzed two stereocentered Hydrolytic Kinetic Resolution (HKR) of racemic 1,3-azido epoxide with good yields and high optical purity without any protecting groups. 10 31

  本发明涉及一种改进的合成4-羟基吡哆酸的方法。本发明涉及一种改进的不对称选择性过程，用于通过Co(III) (salen)催化的两个立体中心水解动力学分辨（HKR）合成(2S,4R)-4-羟基吡哆酸，具有良好的产率和高光学纯度，且无需任何保护基团。
• NANOPARTICLES FOR DRUG DELIVERY
  申请人：KNIPP Ralph J.

  公开号：US20150374849A1

  公开（公告）日：2015-12-31

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.

  本发明提供了纳米颗粒、制备纳米颗粒的方法以及使用纳米颗粒的方法。药物输送系统的一个重要属性是其能够允许空间和时间调节药物释放，从而最大限度地减少副作用并提高传统药物的治疗效果。铁氧化物纳米颗粒（NPs），特别是Fe304纳米颗粒，具有许多适当的特性，使它们成为药物输送的可行选择。
• The compound 1,4-diisopropyl-2,5-diketopiperazine
  申请人：Monsanto Company

  公开号：EP0216744A2

  公开（公告）日：1987-04-01

  The novel compound 1,4-diisopropyl-2,5-diketo­piperazine can be hydrolytically cleaved to prepare N-isopropylglycine, which can be reacted with formal­dehyde and phosphorous acid to produce N-isopropyl-N­phosphonomethylglycine. The latter compound can be dealkylated in the presence of base to produce N-phos­phonomethylglycine, a well known herbicide.

  新型化合物 1,4-二异丙基-2,5-二酮哌嗪可通过水解裂解制备出 N-异丙基甘氨酸，后者可与甲醛和磷酸反应生成 N-异丙基-N-膦酰甲基甘氨酸。后一种化合物可在碱存在下脱烷基，生成 N-膦酰甲基甘氨酸，这是一种众所周知的除草剂。
• Process for the synthesis of N-acetyl amino acids from olefins, acetamide and syngas
  申请人：TEXACO DEVELOPMENT CORPORATION

  公开号：EP0207580B1

  公开（公告）日：1989-07-26