N,N-tetramethylene(ethoxy)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N,N-tetramethylene(ethoxy)acetamide
• 英文别名: 2-Ethoxy-1-pyrrolidin-1-ylethanone
• 化学式: C₈H₁₅NO₂
• mdl: MFCD03929269
• 分子量: 157.213
• InChiKey: SZSWCRYFLHAAEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 重氮乙酸乙酯 以 四氢呋喃 为溶剂， 反应 4.0h， 以15%的产率得到N,N-tetramethylene(ethoxy)acetamide
  参考文献：
  名称：

  Oku, Akira; Kimura, Kenji; Ohwaki, Shigeyoshi, Acta Chemica Scandinavica, 1993, vol. 47, # 4, p. 391 - 397

  摘要：

  DOI：

文献信息

• NAMPT AND ROCK INHIBITORS
  申请人：Curtin Michael L.

  公开号：US20120122842A1

  公开（公告）日：2012-05-17

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

  公开了一种抑制NAMPT活性的化合物，包含该化合物的组合物和治疗NAMPT表达疾病的方法。公开了一种抑制ROCK活性的化合物，包含该化合物的组合物和治疗ROCK表达疾病的方法。
• 2,4-Pyrimidinediamine Compounds And Uses As Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20080009484A1

  公开（公告）日：2008-01-10

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• 2,4-Pyrimidinediamine Compounds and Uses as Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20110190271A1

  公开（公告）日：2011-08-04

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• US7884111B2
  申请人：——

  公开号：US7884111B2

  公开（公告）日：2011-02-08
• US9302989B2
  申请人：——

  公开号：US9302989B2

  公开（公告）日：2016-04-05