alpha-(3,4-Dimethoxyphenethylimino)-alpha-methyl-O-cresol | 58199-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: alpha-(3,4-Dimethoxyphenethylimino)-alpha-methyl-O-cresol
• 英文别名: 2-[N-[2-(3,4-dimethoxyphenyl)ethyl]-C-methylcarbonimidoyl]phenol
• CAS: 58199-65-8
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: DTTZPBCSBHBWMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  alpha-(3,4-Dimethoxyphenethylimino)-alpha-methyl-O-cresol 、 copper(II) acetate monohydrate 以 甲醇 为溶剂， 反应 0.75h， 以87%的产率得到
  参考文献：
  名称：

  来源于高藜芦胺的NO Schiff碱均质锌和铜配合物的合成，结构表征，抗菌和DNA结合研究

  摘要：

  摘要由2-二甲基（3-，4-二甲氧基苯基）乙烷-1-胺（5）衍生的两个席夫碱配体（L1H和L2H）的四个新的均配锌（1和2）和铜（3和4）配合物合成了多巴胺的衍生物。通过元素分析，FT-IR和UV-Vis。，光谱学对这四个复合物进行了很好的表征。此外，锌配合物（1和2）通过1H和13C {1H} NMR光谱表征，而铜配合物（3和4）通过单晶X射线衍射表征。配合物的表征数据显示，去质子化配体（L1和L2）作为组分[Zn / Cu（L1-2）2]的NO供体，通过甲亚胺氮（N）和苯酚氧（O）具有很强的配位作用（1-4）。复合物的CT-DNA结合亲和力1，使用电子吸收滴定法评估图2和图4，该图显示了通过嵌入模式的狂热结合，发现结合常数（Kb）约为105–106 M-1。通过琼脂井扩散方法针对致病性抗菌菌株大肠杆菌，金黄色葡萄球菌和抗真菌菌株白色念珠菌筛选化合物（1-5）的剂量依赖性抗菌活性。该化合物对这些病原体显示出显着的毒性。

  DOI：

  10.1016/j.ica.2019.05.028
• 作为产物：
  描述：

  2'-羟基苯乙酮 、 3,4-二甲氧基苯乙胺 以 乙醇 为溶剂， 反应 2.0h， 生成 alpha-(3,4-Dimethoxyphenethylimino)-alpha-methyl-O-cresol
  参考文献：
  名称：

  含（N，O）Schiff碱配体的半三明治Ru（II）配合物：酮的无碱转移加氢催化剂

  摘要：

  合成了两种新的含多巴胺基（N，O）Schiff碱配体（L 1 H和L 2 H）的Ru（II）（p- cymene）半三明治Ru（II）（p- cymene）配合物（1和2），并通过FT-IR表征UV-Visible和1 H＆13 C NMR光谱技术，以及元素分析。光谱和分析数据显示配体与Ru离子的一元二齿配位。L 1 H，L 2 H和2的分子结构通过单晶X射线衍射研究进一步证实。复合体1和2 在85°C无碱条件下，以2-丙醇为氢源，用作酮的转移氢化催化剂。仲醇的优异收率，克规模的合成以及较高的TON和TOF都使该催化体系变得有趣。

  DOI：

  10.1002/aoc.5111

文献信息

• Half‐sandwich Ru (II) complexes containing (N, O) Schiff base ligands: Catalysts for base‐free transfer hydrogenation of ketones
  作者：C.E. Satheesh、Pushpanathan N. Sathish Kumar、P. Raghavendra Kumara、Ramasamy Karvembu、Amar Hosamani、M. Nethaji

  DOI：10.1002/aoc.5111

  日期：2019.10

  Two new half‐sandwich Ru (II)(p‐cymene) complexes (1 and 2) containing dopamine‐based (N, O) Schiff base ligands (L1H and L2H) were synthesized and characterized by FT‐IR, UV–Visible and 1H & 13C NMR spectral techniques, and elemental analyses. The spectroscopic and analytical data revealed monobasic bidentate coordination of the ligands with Ru ion. The molecular structures of L1H, L2H and 2 were

  合成了两种新的含多巴胺基（N，O）Schiff碱配体（L 1 H和L 2 H）的Ru（II）（p- cymene）半三明治Ru（II）（p- cymene）配合物（1和2），并通过FT-IR表征UV-Visible和1 H＆13 C NMR光谱技术，以及元素分析。光谱和分析数据显示配体与Ru离子的一元二齿配位。L 1 H，L 2 H和2的分子结构通过单晶X射线衍射研究进一步证实。复合体1和2 在85°C无碱条件下，以2-丙醇为氢源，用作酮的转移氢化催化剂。仲醇的优异收率，克规模的合成以及较高的TON和TOF都使该催化体系变得有趣。
• Synthesis, characterisation and antimicrobial activity of new palladium and nickel complexes containing Schiff bases
  作者：C.E. Satheesh、P. Raghavendra Kumar、P. Sharma、K. Lingaraju、B.S. Palakshamurthy、H. Raja Naika

  DOI：10.1016/j.ica.2015.11.017

  日期：2016.3

  New Schiff base ligands were synthesized by condensation of 2-(3,4-dimethoxyphenyl)ethanamine with 2-hydroxy benzaldehyde ((LH)-H-1) and 2'-hydroxy acetophenone ((LH)-H-2) respectively. Reaction of (LH)-H-1 or (LH)-H-2 with Na2PdCl4 or NiCl2 center dot 6H(2)O in 2:1 ratio obtained four new coordination complexes [M(L1-2)(2)] (where M = Pd(II); 1 and 2 and M = Ni(II); 3 and 4). Both the ligands and four complexes were characterised by elemental analysis, FT-IR and UV-Vis, spectroscopy. (LH)-H-1, (LH)-H-2, 1 and 2 were also characterised by H-1 and C-13H-1} NMR spectroscopy. The molecular structures of 1 and 3 were determined by single crystal X-ray diffraction. The spectroscopic and crystal structure data showed that the ligands coordinated to M (II) ion in a bidentate monoanionic (O , N) fashion. The Pd-O and Pd-N bond lengths in 1 are 1.984(11) and 2.020(12) angstrom in 3 the Ni-O and Ni-N bond lengths are 1.8222(13) and 1.9262(15) angstrom respectively. The C=N bond length in 3 found 1.290(2) angstrom which was shorter than 1.310(19) angstrom in 1. The bond angles provided square planar geometry around Pd(II) and Ni(II) in both 1 and 3. There exists C-H center dot center dot center dot O type (2.50-2.52 angstrom) intermolecular hydrogen bonding in both 1 and 3 resulting in supramolecular structures. The antimicrobial activity of new Schiff base ligands and their Pd(II) and Ni(II) complexes against pathogenic microbial strains by agar well diffusion method was conducted. All the ligands and complexes showed significant antibacterial and antifungal activities. The bacterial and fungi growth inhibition activity of ligands has been increased on complexation as well as among complexes palladium complexes were found better antibacterial and antifungal agents than the nickel complexes of corresponding ligands. Ligand (LH)-H-1 and the complex 2 showed highest antibacterial activity against Pseudomonas desmolyticum and highest antifungal activity against Candida albicans. (C) 2015 Elsevier B.V. All rights reserved.
• Synthesis, structural characterization, antimicrobial and DNA binding studies of homoleptic zinc and copper complexes of NO Schiff bases derived from homoveratrylamine
  作者：C.E. Satheesh、P. Raghavendra Kumar、N. Shivakumar、K. Lingaraju、P. Murali Krishna、H. Rajanaika、Amar Hosamani

  DOI：10.1016/j.ica.2019.05.028

  日期：2019.9

  Abstract Four new homoleptic zinc (1 and 2) and copper (3 and 4) complexes of two Schiff base ligands (L1H and L2H) derived from 2-(3,4-dimethoxyphenyl)ethan-1-amine (5), a dimethyl derivative of dopamine were synthesized. All four complexes were well characterized by elemental analysis, FT-IR and UV–Vis., spectroscopy. Further, the zinc complexes (1 and 2) were characterized by 1H and 13C1H} NMR

  摘要由2-二甲基（3-，4-二甲氧基苯基）乙烷-1-胺（5）衍生的两个席夫碱配体（L1H和L2H）的四个新的均配锌（1和2）和铜（3和4）配合物合成了多巴胺的衍生物。通过元素分析，FT-IR和UV-Vis。，光谱学对这四个复合物进行了很好的表征。此外，锌配合物（1和2）通过1H和13C 1H} NMR光谱表征，而铜配合物（3和4）通过单晶X射线衍射表征。配合物的表征数据显示，去质子化配体（L1和L2）作为组分[Zn / Cu（L1-2）2]的NO供体，通过甲亚胺氮（N）和苯酚氧（O）具有很强的配位作用（1-4）。复合物的CT-DNA结合亲和力1，使用电子吸收滴定法评估图2和图4，该图显示了通过嵌入模式的狂热结合，发现结合常数（Kb）约为105–106 M-1。通过琼脂井扩散方法针对致病性抗菌菌株大肠杆菌，金黄色葡萄球菌和抗真菌菌株白色念珠菌筛选化合物（1-5）的剂量依赖性抗菌活性。该化合物对这些病原体显示出显着的毒性。