dihydro-3-(1-oxo-2-phenyl-2-propenyl)furan-2-one | 677325-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dihydro-3-(1-oxo-2-phenyl-2-propenyl)furan-2-one
• 英文别名: 3-(2-Phenylprop-2-enoyl)oxolan-2-one
• CAS: 677325-07-4
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: GOBOYSMOTZVMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dihydro-3-(1-oxo-2-phenyl-2-propenyl)furan-2-one 在 ammonium hydroxide 、 氯化铵 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以44%的产率得到hexahydro-7a-hydroxy-7-phenylfuro[3,2-c]pyridin-4-one
  参考文献：
  名称：

  Model Studies and First Synthesis of the Antifungal and Antibacterial Agent Cladobotryal

  摘要：

  The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO2SiPr-i(3) group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product.

  DOI：

  10.1021/jo030284g
• 作为产物：
  描述：

  阿托醛 在 正丁基锂 、 戴斯-马丁氧化剂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 dihydro-3-(1-oxo-2-phenyl-2-propenyl)furan-2-one
  参考文献：
  名称：

  Model Studies and First Synthesis of the Antifungal and Antibacterial Agent Cladobotryal

  摘要：

  The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO2SiPr-i(3) group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product.

  DOI：

  10.1021/jo030284g

文献信息

• Model Studies and First Synthesis of the Antifungal and Antibacterial Agent Cladobotryal
  作者：Derrick L. J. Clive、Xiaojun Huang

  DOI：10.1021/jo030284g

  日期：2004.3.1

  The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO2SiPr-i(3) group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product.