3-(2-hydroxyphenyl)-6-(3-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(2-hydroxyphenyl)-6-(3-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one
• 英文别名: 3-(2-hydroxyphenyl)-6-(3-methoxyphenyl)-1,4-dihydropyrimidin-2-one
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.32
• InChiKey: WZBDYTYHKOBUIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel compounds and their uses
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040067970A1

  公开（公告）日：2004-04-08

  Use of a compound according to Formula [I]: 1 or a salt thereof to produce a cooling sensation, wherein R 1 and R 2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups: or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, with the proviso that when R 1 is 2-hydroxyphenyl, R 2 is other than 3-nitrophenyl.

  使用式[I]中的化合物或其盐可产生冷却感，其中R1和R2分别选择自氢原子或卤素原子；羟基、氰基、硝基、巯基、羰基、砜基和羧基基团；或者是选择性取代的烷基、烯基、烷氧基、烷硫基、芳基、芳氧基、芳硫基、氨基、硅氧基、酯基和杂环基团，但是当R1为2-羟基苯基时，R2不能为3-硝基苯基。
• TETRAHYDROPYRIMIDINE-2-ONE DERIVATIVES AND THEIR USES
  申请人：UNILEVER PLC

  公开号：EP1546114A1

  公开（公告）日：2005-06-29
• Composition
  申请人：Freunscht Peter

  公开号：US20060280697A1

  公开（公告）日：2006-12-14

  An oral care composition, comprising: a therapeutically effective amount of a cooling compound having the structure of Formula [I]: or a salt thereof to produce a cooling sensation, wherein R 1 and R 2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups; or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, characterised by an oil soluble agent for solubilising or emulsifying the cooling compound.
• US7045624B2
  申请人：——

  公开号：US7045624B2

  公开（公告）日：2006-05-16
• [EN] TETRAHYDROPYRIMIDINE-2-ONE DERIVATIVES AND THEIR USES<br/>[FR] DERIVES DE TETRAHYDROPYRIMIDINE-2-ONE ET LEURS UTILISATIONS
  申请人：UNILEVER PLC

  公开号：WO2004026840A1

  公开（公告）日：2004-04-01

  Use of a compound according to Formula [I] or a salt thereof to produce a cooling sensation, wherein R1 and R2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups; or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, with the proviso that when R1 is 2-hydroxyphenyl, R2 is other than 3-nitrophenyl.