N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)nonanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)nonanamide
• 化学式: C₁₆H₃₃NO₆
• 分子量: 335.44
• InChiKey: GCRLIVCNZWDCDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  122
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• SUGAR SURFACTANTS AND USE THEREOF IN AGROCHEMICAL COMPOSITIONS
  申请人：Clariant International Ltd.

  公开号：US20170339949A1

  公开（公告）日：2017-11-30

  A sugar surfactant of formula (I), where R 1 is H or an alkyl group comprising 1 to 3 carbon atoms and R 2 is a polyhydroxyhydrocarbyl group comprising a straight hydrocarbyl chain to which at least three hydroxyl groups are directly bonded, preferably a 2,3,4,5,6-pentahydroxyhex-1-yl group, is suitable especially for use in agrochemical adjuvant and active substance compositions.

  一种糖基表面活性剂，其化学式为（I），其中R1为H或含有1至3个碳原子的烷基基团，R2为聚羟基烃基团，包括直链烃基链，至少有三个羟基直接连接在上面，最好是2,3,4,5,6-五羟基己-1-基基团，特别适用于农药助剂和活性物质组合物中的使用。
• Compositions and methods for delivery of agents
  申请人：ModernaTX, Inc.

  公开号：US10207010B2

  公开（公告）日：2019-02-19

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  本公开提供了改进的脂基组合物（包括脂质纳米颗粒组合物）及其使用方法，用于在体内递送包括核酸和蛋白质在内的制剂。这些组合物不会加速血液清除，而且在体内具有更好的毒性特征。
• COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS
  申请人：ModernaTX, Inc.

  公开号：US20180028664A1

  公开（公告）日：2018-02-01

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
• ACTIVE INGREDIENT COMPOSITIONS COMPRISING N-ALKENOYL-N-ALKYLGLUCAMIDES AND THE USE THEREOF
  申请人：Clariant International, Ltd.

  公开号：US20190110472A1

  公开（公告）日：2019-04-18

  The invention relates to active ingredient compositions comprising a) one or more active substances, and b) one or more N-alkenoyl-N-alkylglucamides of the formula I in which R1 is a linear or branched alkenyl group which has 7 to 16 carbon atoms and has a non-terminal double bond or a plurality of conjugated or non-conjugated double bonds, and R2 is an alkyl group having 1 to 4 carbon atoms. The compounds of formula I can be used for reducing drift and for improving wettability when appyling active ingredient compositions.