N-methyl-N-tert-butoxycarbonyl-O-acetylhydroxylamine | 19689-96-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-N-tert-butoxycarbonyl-O-acetylhydroxylamine
• 英文别名: [Methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino] acetate
• CAS: 19689-96-4
• 化学式: C₈H₁₅NO₄
• 分子量: 189.211
• InChiKey: ZOSBEVURFQWRKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-methyl-N-tert-butoxycarbonyl-O-acetylhydroxylamine 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以95%的产率得到N-methyl-O-acetylhydroxylamine hydrochloride
  参考文献：
  名称：

  A General Method for the α-Acyloxylation of Carbonyl Compounds

  摘要：

  A simple, one-pot method for the alpha-acyloxylation of carbonyl compounds that proceeds at room temperature in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acyclic ketones with N-methyl-O-benzoylhydroxylamine hydrochloride provides the alpha-functionalized product in 69-92% isolated yield. The transformation is tolerant of a wide range of functional groups and, significantly, is reglospecific in the discrimination of secondary over primary centers in the case of nonsymmetrical substrates.

  DOI：

  10.1021/ol052474e
• 作为产物：
  描述：

  N-羟基-N-甲基氨基甲酸叔丁酯 、 乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到N-methyl-N-tert-butoxycarbonyl-O-acetylhydroxylamine
  参考文献：
  名称：

  A General Method for the α-Acyloxylation of Carbonyl Compounds

  摘要：

  A simple, one-pot method for the alpha-acyloxylation of carbonyl compounds that proceeds at room temperature in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acyclic ketones with N-methyl-O-benzoylhydroxylamine hydrochloride provides the alpha-functionalized product in 69-92% isolated yield. The transformation is tolerant of a wide range of functional groups and, significantly, is reglospecific in the discrimination of secondary over primary centers in the case of nonsymmetrical substrates.

  DOI：

  10.1021/ol052474e

文献信息

• [EN] CEPHEM COMPOUNDS<br/>[FR] COMPOSES CEPHEME
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004039814A1

  公开（公告）日：2004-05-13

  The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is ; R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

  本发明涉及一种具有以下式[I]的化合物：其中R1是较低的烷基、羟基(较低)烷基或卤代(较低)烷基，R2是氢或氨基保护基，或者R1和R2结合在一起形成较低的烷基或较低的烯基；R3是氢或较低的烷基；R4是；R5是羧基或保护羧基；R6是氨基或保护氨基，或其药学上可接受的盐，一种制备上述式[I]化合物的方法，以及包含上述式[I]化合物与药学上可接受的载体混合物的药物组合物。
• QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION
  申请人：OTSUBO Kenji

  公开号：US20130005675A1

  公开（公告）日：2013-01-03

  The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R 1 represents hydrogen or the like; R 2 represents hydrogen or the like; R 3 represents substituted or unsubstituted phenyl or the like; R 4 represents halogen or the like; R 5 represents hydrogen or the like; R 6 represents hydrogen or the like; and R 7 represents hydrogen or the like.

  本发明提供一种喹诺酮化合物，该化合物能够抑制帕金森病的慢性进展或保护多巴胺神经元免受疾病因素的影响，从而抑制神经功能障碍的进展，延长L-多巴胺给药时间，并改善神经元功能；该发明的喹诺酮化合物由式（1）表示：其中：R1代表氢或类似物；R2代表氢或类似物；R3代表取代或未取代的苯基或类似物；R4代表卤素或类似物；R5代表氢或类似物；R6代表氢或类似物；R7代表氢或类似物。
• N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES
  申请人：The Johns Hopkins University

  公开号：US20160046570A1

  公开（公告）日：2016-02-18

  The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

  本发明提供了某些N-酰氧磺酰胺和N-羟基-N-酰基磺酰胺衍生物化合物，包括这些化合物的制药组合物和试剂盒，以及使用这些化合物或制药组合物的方法。特别地，本发明提供了使用这些化合物或制药组合物治疗、预防或延缓疾病或病况发生和/或发展的方法。在某些实施例中，所述疾病或病况被选择自心血管疾病、缺血、再灌注损伤、癌症疾病、肺动脉高压和对亚硝酰治疗有反应的病况。
• CEPHEM COMPOUNDS
  申请人：Astellas Pharma Inc.

  公开号：EP1556389A1

  公开（公告）日：2005-07-27
• US5705504A
  申请人：——

  公开号：US5705504A

  公开（公告）日：1998-01-06