2-(4-aminobenzyloxy)ethanol | 1019516-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-aminobenzyloxy)ethanol
• 英文别名: 2-[(4-Aminophenyl)methoxy]ethan-1-ol；2-[(4-aminophenyl)methoxy]ethanol
• CAS: 1019516-04-1
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: KCEUZSSHEIYWEN-UHFFFAOYSA-N

物化性质

• 沸点：
  329.0±22.0 °C(Predicted)
• 密度：
  1.153±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-aminobenzyloxy)ethanol 在 barium dihydroxide 、 三乙胺 、 barium(II) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2,2-dimethyl-N-[4-(2-phenylmethoxyethoxymethyl)phenyl]propanamide
  参考文献：
  名称：

  4-Pivaloylaminobenzyl ether, a new temporary protection for hydroxyl functions

  摘要：

  4-Pivaloylaminobenzyl (PAB) group is a new benzyl-type protecting group which can be introduced either by initial introduction of 4-nitrobenzyl group followed by reduction and N-acylation or by the reaction of a hydroxyl compound with the corresponding halogenide or trichloroacetimidate. PAB ethers have higher acid stability than 4-methoxybenzyl ethers but are readily cleaved with DDQ in a manner similar to the latter.

  DOI：

  10.1016/0040-4039(91)80616-e
• 作为产物：
  描述：

  2-(4'-nitrobenzyloxy)ethanol 在 氢气 作用下， 25.0 ℃ 、500.01 kPa 条件下， 以81 %的产率得到2-(4-aminobenzyloxy)ethanol
  参考文献：
  名称：

  Ionic Liquid Immobilized Pd Nanocatalysts for Chemoselective Reduction of Aliphatic/Aromatic Nitro Compounds

  摘要：

  摘要 在这项工作中，我们成功合成了四种离子液体介导的 Pd 纳米催化剂，并利用透射电子显微镜 (TEM)、X 射线衍射分析 (XRD)、X 射线衍射分析 (XRD) 透射电子显微镜 (TEM)、X 射线衍射分析 (XRD)、X 射线光电子能谱 (XPS) 光谱（XPS）和原子吸收光谱（AAS）分析。分散良好且细小的 在 ILPdNPs-4 催化体系中记录到了分散良好且细小的钯纳米颗粒。我们利用这种催化体系 还原了一系列带有硝基的脂肪族和芳香族化合物，并开发出了多种具有生物活性的胺分子。 胺分子。此外，我们还还原了硝基内酯。 硝基内酯被认为是合成肾素抑制剂阿利吉仑（Tekturna®, et al. (Tekturna®，在全球被称为 Rasilez®）的重要起始原料之一。我们还完成了催化剂稳定性测试，并回收了 ILPdNPs-4 催化系统进行了多达八次运行。在回收过程中，没有发现金属浸出、钯黑形成和结块的迹象。 在循环运行过程中，没有记录到金属浸出、钯黑形成和结块的迹象。

  DOI：

  10.2174/1570178620666230622152510

文献信息

• Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium
  作者：Randhir Rai、Dillip Kumar Chand

  DOI：10.1007/s12039-021-01940-3

  日期：2021.9

  established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds

  摘要 建立了从CuSO 4 ·5H 2 O实际合成CuNPs 的程序，在适当的反应条件下，使用水稻（Oryza sativa）作为还原剂和稳定剂的经济来源。光学和显微技术用于表征合成的 CuNPs，发现颗粒的尺寸在 8 ± 2 nm 的范围内。纳米颗粒用作催化剂，用于在环境条件下将芳香族硝基化合物化学选择性还原为相应的胺，水作为反应介质。 图形摘要 CuNPs 是使用水解大米合成的，并用作催化剂将硝基芳烃化学选择性还原为其相应的胺在水中。
• Synthesis and biological evaluation of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents
  作者：Li Wang、Fenyan Yang、Xiaochun Yang、Xianghong Guan、Chunqi Hu、Tao Liu、Qiaojun He、Bo Yang、Yongzhou Hu

  DOI：10.1016/j.ejmech.2010.11.016

  日期：2011.1

  A series of new 4 beta-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4 beta position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route. (C) 2010 Elsevier Masson SAS. All rights reserved.
• 4-Pivaloylaminobenzyl ether, a new temporary protection for hydroxyl functions
  作者：Koichi Fukase、Takuya Yoshimura、Manabu Hashida、Shoichi Kusumoto

  DOI：10.1016/0040-4039(91)80616-e

  日期：1991.8

  4-Pivaloylaminobenzyl (PAB) group is a new benzyl-type protecting group which can be introduced either by initial introduction of 4-nitrobenzyl group followed by reduction and N-acylation or by the reaction of a hydroxyl compound with the corresponding halogenide or trichloroacetimidate. PAB ethers have higher acid stability than 4-methoxybenzyl ethers but are readily cleaved with DDQ in a manner similar to the latter.