N-pyrrol-1-ylprop-2-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-pyrrol-1-ylprop-2-enamide
• 化学式: C₇H₈N₂O
• 分子量: 136.15
• InChiKey: XLVGHHWPFWEHJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1309590A1

  公开（公告）日：2003-05-14
• [EN] AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS<br/>[FR] DERIVES D'AZAINDOLE, PROCEDE DE PREPARATION ET LEUR UTILISATION EN TANT QU'AGENTS ANTITUMORAUX
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2001098299A1

  公开（公告）日：2001-12-27

  Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.