(2R)-3-cyclohexyl-2-sulfanylpropanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R)-3-cyclohexyl-2-sulfanylpropanoic acid
• 化学式: C₉H₁₆O₂S
• 分子量: 188.29
• InChiKey: SJVKYBGOVCEKDX-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] ANTI-GM1 ANTIBODY BINDING COMPOUNDS<br/>[FR] COMPOSÉS DE LIAISON À UN ANTICORPS ANTI-GM1
  申请人：[en]POLYNEURON PHARMACEUTICALS AG

  公开号：WO2022224035A2

  公开（公告）日：2022-10-27

  This disclosure provides glycan-conjugated compounds that specifically bind to anti -GM1 autoantibodies. These glycan-conjugated compounds can include a polymer backbone or support configured to display multiple glycan groups that are designed to mimic the natural GM1 epitope. The glycan-conjugated compounds can also be configured on a solid support. The linked glycan groups can be a novel analogue of the GM1 epitope. When several such glycan groups are configured on a polymeric backbone, the resulting compound provides for potent and specific binding to anti-GM1 IgG and IgM isotype autoantibodies in patient sera. This disclosure thus provides glycan-containing compounds of formula (I) that mimic the natural GM1 epitope, and therapeutically useful polymers that include a multitude of such ligands, designed to bind anti-GM1 antibodiesin vitrofor diagnostic use, and to sequester and eliminate anti-GM1 antibodiesin vivoor extracorporeal (ex vivo) for the treatment anti-GM1 autoantibody related neuropathies.