[(2R)-2-Butanoyloxy-3-carboxypropyl]-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [(2R)-2-Butanoyloxy-3-carboxypropyl]-trimethylazanium
• 化学式: C11H22NO4+
• 分子量: 232.3
• InChiKey: QWYFHHGCZUCMBN-SECBINFHSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME<br/>[FR] PHYTATES DE L-CARNITINE ET D'ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SCIAN LAB LLC

  公开号：WO2010005465A1

  公开（公告）日：2010-01-14

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和烷酰基L-肉碱盐与一般公式(I)的植酸，以及制备这些化合物的过程，其中L-肉碱或其烷酰衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n = 1-6；R1为植酸阴离子；R为氢、具有2-12个碳原子的直链烷酰基团或具有2-12个碳原子的支链烷酰基团。
• L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
  申请人：Chen Jian

  公开号：US20100317890A1

  公开（公告）日：2010-12-16

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R 1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和辛酰基L-肉碱盐与通式(I)的植酸，以及其制备方法，其中L-肉碱或其辛酰基衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n=1-6；R1是植酸阴离子；R是氢，具有2-12个碳原子的直链辛酰基或具有2-12个碳原子的支链辛酰基。
• METHODS FOR DIAGNOSING PANCREATIC CANCER
  申请人：metanomics Health GmbH

  公开号：EP3502699A1

  公开（公告）日：2019-06-26

  The present invention relates to a method for diagnosing pancreatic cancer in a subject suspected to suffer from pancreatic cancer comprising the steps of: (a) determining in a sample of said subject the value of (i) at least one biomarker of the categories carnitines, amino acids, and mitochondrial energy metabolites, and (ii) a first and a second sphingolipid, wherein the fatty acid residue of the first sphingolipid is at least four carbon atoms longer than the fatty acid residue of the second sphingolipid, and wherein the sphingosine backbone of the first sphingolipid and the second sphingolipid are identical; and (b) comparing the values of the biomarkers with references, whereby pancreatic cancer is diagnosed; and to a method for identifying whether a subject is in need of a pancreatic cancer therapy related thereto. The present invention further relates to a device for diagnosing pancreatic cancer in a sample of a subject comprising (a) an analyzing unit for the sample of the subject comprising a detector for the amounts of at least one biomarker each of the categories carnitines, amino acids, energy metabolites, and sphingolipids; said detector allowing for the determination of the amounts of the biomarkers of the said group of biomarkers in the sample; and operatively linked thereto, (b) an evaluation unit comprising a data processing unit and a data base, said data base comprising a stored reference and said data processing unit having tangibly embedded an algorithm for carrying out a comparison of the amounts of the biomarkers of the group of biomarkers determined by the analyzing unit and the stored reference and for generating an output information based on which the diagnosis can be established. Further, the present invention relates to a data collection and too a use related to the aforesaid subject matter.

  本发明涉及一种对疑似胰腺癌患者进行胰腺癌诊断的方法，包括以下步骤：(a) 在所述受试者的样本中确定(i)至少一种肉碱类、氨基酸类和线粒体能量代谢产物类生物标志物的值，以及(ii)第一和第二鞘脂的值，其中第一鞘脂的脂肪酸残基比第二鞘脂的脂肪酸残基至少长四个碳原子，并且第一鞘脂和第二鞘脂的鞘磷脂骨架相同；(b) 将生物标志物的值与参考值进行比较，从而诊断出胰腺癌；以及一种用于确定受试者是否需要接受与此相关的胰腺癌治疗的方法。本发明还涉及一种用于诊断受试者样本中的胰腺癌的装置，该装置包括 (a) 用于受试者样本的分析单元，该单元包括一个检测器，用于检测肉碱类、氨基酸类、能量代谢产物类和鞘磷脂类中至少一种生物标记物的含量；所述检测器可用于确定样本中所述生物标记物组的生物标记物含量；(b) 由数据处理单元和数据库组成的评估单元，所述数据库包括已存储的参照物，所述数据处理单元有形地嵌入了一种算法，用于将分析单元确定的生物标志物组中的生物标志物的数量与已存储的参照物进行比较，并生成输出信息，据此确定诊断结果。此外，本发明还涉及与上述主题相关的数据收集和使用。
• METHOD FOR DETERMINING THE EXTENT OF AGING OF A SUBJECT AND TREATING THE SUBJECT TO SUPPRESS THE EXTENT OF AGING
  申请人：OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

  公开号：US20190101525A1

  公开（公告）日：2019-04-04

  A method for suppressing aging includes obtaining a blood sample from a subject, detecting one or more blood metabolites in the blood sample, identifying the subject as having a biological age greater than a chronological age of the subject by determining metabolite levels of the one or more blood metabolites of the subject, and subjecting the identified subject to fasting more than 10 hours.
• US8067468B2
  申请人：——

  公开号：US8067468B2

  公开（公告）日：2011-11-29