3-Dodecanoyloxy-2-hydroxypropane-1-sulfonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Dodecanoyloxy-2-hydroxypropane-1-sulfonic acid
• 化学式: C₁₅H₃₀O₆S
• 分子量: 338.5
• InChiKey: QSCVMVDOAMAIHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Method of serum pre-treatment for glycomic analysis
  申请人：Nishimura Shin-Ichiro

  公开号：US20090187011A1

  公开（公告）日：2009-07-23

  A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention. A salt of the general formula (I): wherein Z, X, R 1 , R 2 , M, m and n are the same as described in DESCRIPTION, is useful as a protein solubilizer, and an oligosaccharide is efficiently released from a sample if reductive alkylation and/or digestion by a proteinase are carried out under the presence of the said solubilizer at the first step in the glycomic analysis of glycoprotein derived from a living body.

  本发明提供了一种糖蛋白质糖组学分析的预处理手段。通式（I）的盐在蛋白质溶解剂方面具有用途，如果在糖蛋白质的糖组学分析的第一步中，在所述溶解剂的存在下进行还原烷基化和/或蛋白酶消化，则样品中的寡糖可以高效地释放，其中Z、X、R1、R2、M、m和n如描述中所述。
• APPARATUS FOR AUTO-PRETREATING SUGAR CHAIN
  申请人：Hokkaido University

  公开号：EP2207030A1

  公开（公告）日：2010-07-14

  To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.

  提供一种自动分析仪，用于分析生物样品，特别是血清中含有的糖链。即提供一种分析样品中糖链的方法，该方法包括以下步骤：A) 糖链释放步骤，释放样品中的糖链；B) 检测样品制备步骤，制备释放的糖链用于检测；以及，在使用平板进行质谱分析的情况下，C) 形成质谱分析用平板的步骤，平板上点缀有捕获的糖链，该步骤包括将步骤 B) 中获得的标记糖链样品溶液提供到收集平板上；如果需要，在固相支撑封闭板中进行操作以形成用于质谱分析的板的步骤；以及 D) 分析待测糖链的步骤。
• US8058409B2
  申请人：——

  公开号：US8058409B2

  公开（公告）日：2011-11-15
• US8877454B2
  申请人：——

  公开号：US8877454B2

  公开（公告）日：2014-11-04