N-[苯基(哌啶-1-基)甲基]苯甲酰胺 | 15563-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[苯基(哌啶-1-基)甲基]苯甲酰胺
• 英文名称: piperidinobenzyl benzamide
• 英文别名: PBB；N-(phenyl-piperidin-1-yl-methyl)-benzamide；N-(α-piperidino-benzyl)-benzamide；N-(α-Piperidino-benzyl)-benzamid；Benzamide, N-(phenyl-1-piperidinylmethyl)-；N-[phenyl(piperidin-1-yl)methyl]benzamide
• CAS: 15563-53-8
• 化学式: C₁₉H₂₂N₂O
• 分子量: 294.396
• InChiKey: NVVFLNPPJPMLEF-UHFFFAOYSA-N

物化性质

• 熔点：
  148-149 °C(Solv: ligroine (8032-32-4))
• 沸点：
  484.7±38.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[苯基(哌啶-1-基)甲基]苯甲酰胺 在 溶剂黄146 作用下， 生成 N-[羟基(苯基)甲基]苯甲酰胺
  参考文献：
  名称：

  Leuckart-Wallach反应路径的研究

  摘要：

  Leuckart-Wallach 反应路径通过 Leuckart-Wallach 反应系统中的催化还原并基于类似的甲酸还原进行研究。已经确定，在 Leuckart-Wallach 反应的早期阶段，氨、胺和甲酰胺与羰基化合物发生加成反应。由甲酸催化的甲酰胺的添加仅对反应性更强的底物如苯甲醛起重要作用。在类似甲酸还原的数据的基础上讨论了可能的甲酸还原中间体的行为。

  DOI：

  10.1246/bcsj.49.2485
• 作为产物：
  描述：

  哌啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 以87%的产率得到N-[苯基(哌啶-1-基)甲基]苯甲酰胺
  参考文献：
  名称：

  Monoacylaminals by the Benzotriazole-Assisted Aminoalkylation of Amides

  摘要：

  DOI：

  10.1055/s-1998-2164

文献信息

• The Preparation of Some<i>N</i>- and<i>S</i>-Acetals of Benzaldehyde and Terephthalaldehyde
  作者：Alan R. Katritzky、Maria Szajda、Shibli Bayyuk

  DOI：10.1055/s-1986-31786

  日期：——

  Improved preparative methods are reported for title compounds of types comprising aminonitriles, amidoamines, amidothioethers, and aminothioethers.

  报告改进了由氨基硝酸酯、氨基胺、氨基硫醚和氨基硫醚组成的标题化合物的制备方法。
• Peroxo complexes of uranium(VI) containing nitrogen and oxygen donor ligands
  作者：Balgar Singh、Simpy Mahajan、H. N. Sheikh、Mohita Sharma、Bansi Lal Kalsotra

  DOI：10.1134/s003602361208013x

  日期：2012.8

  The uranium(VI) peroxo complexes containing Mannich base ligands having composition [UO(O-2)L-L(NO3)(2)] where L-L = morpholinobenzyl acetamide (MBA), piperidinobenzyl acetamide (PBA), morpholinobenzyl benzamide (MBB), piperidinobenzyl benzamide (PBB), morpholinomethyl benzamide (MMB), piperidinomethyl benzamide (PMB), morpholinobenzyl formamide (MBF)}, piperidinobenzyl formamide (PBF) are reported. In a typical reaction UO2(NO3)(2) center dot 6H(2)O (1 mmol, 0.502 g) was dissolved in methanol. An equimolar (1 mmol) methanolic solution (30 mL) of the ligand (Mannich bases) was added to a solution of uranyl nitrate followed by addition of potassium hydroxide (KOH) (2 mmol, 0.1122 g). The solution was refluxed for 15 min and then 10 mL of 30% hydrogen peroxide (H2O2) was added dropwise and was refluxed for an additional 1 h. The synthesized complexes have been characterized by various physico-chemical techniques, viz. elemental analysis, molar conductivity, magnetic susceptibility measurements, infra red, electronic, mass spectral and TGA/DTA studies. These studies revealed that the synthesized complexes are non-electrolytic and diamagnetic in nature. The ligands are bound to metal in a bidentate mode through carbonyl oxygen and the ring nitrogen. Thermal analysis result provides conclusive evidence for the absence of water molecule in the complexes. Mass spectra confirm the molecular mass of the complexes. Antibacterial activity of complexes revealed enhanced activity of complexes as compared to corresponding free ligands. Molecular modeling suggests pentagonal bipyramidal structure for complexes.
• Macovski; Bachmeyer, Chemische Berichte, 1944, vol. 77/79, p. 487,494
  作者：Macovski、Bachmeyer

  DOI：——

  日期：——
• MESSINGER P., PHARMAZIE <PHAR-AT>, 1976, 31, NO 1, 16-18
  作者：MESSINGER P.

  DOI：——

  日期：——
• KATRITZKY A. R.; SZAJDA M.; BAYYUK SHIBLI, SYNTHESIS,(1986) N 10, 804-807
  作者：KATRITZKY A. R.、 SZAJDA M.、 BAYYUK SHIBLI

  DOI：——

  日期：——

表征谱图