3-amino-4-hydroxymethylbenzoate | 861559-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-4-hydroxymethylbenzoate
• 英文别名: 3-Amino-4-(hydroxymethyl)benzoic acid
• CAS: 861559-77-5
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: BWOXWCBFIGNLEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基-4-羟基苯甲酸 以69.9%的产率得到3-amino-4-hydroxymethylbenzoate
  参考文献：
  名称：

  Solid phase synthesis of arylretinamides

  摘要：

  提供了一种用于制备芳基维甲酰胺的固相合成方法。该方法包括将六氯乙酮与悬浮于溶剂中的树脂结合的三苯基膦反应，以提供含有活化氯化试剂的悬浮液；将维甲酸与活化氯化试剂反应以提供维甲酰氯；向得到的混合物中加入吡啶和选择的芳基胺；并在足够时间和温度下搅拌得到的混合物，以使选择的芳基胺与维甲酰氯反应并提供芳基维甲酰胺。还提供了可以通过该方法制备的选择性芳基维甲酰胺，以及使用这些芳基维甲酰胺在癌细胞中诱导凋亡的方法。

  公开号：

  US20030105164A1

文献信息

• Photo-Cleavable Surfactants
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20210253519A1

  公开（公告）日：2021-08-19

  The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications. In addition, the present photo-cleavable anionic surfactants are also suitable for dissolving polypeptides in bottom-up proteomic experiments including extracellular matrix proteomics, and are suitable as a substitute for SDS in gel electrophoresis.

  本发明提供了光解离的阴离子表面活性剂，特别是4-己基苯基偶氮磺酸盐（Azo）和钠4-己基苯基偶氮磺酸盐衍生物，可以在紫外辐射下迅速降解，用于自顶向下和自底向上的蛋白质组学研究。这些表面活性剂可以有效溶解蛋白质和肽段，性能可与十二烷基硫酸钠（SDS）相媲美，并且与质谱分析兼容，可对溶解的蛋白质和肽段进行分析。利用本发明的光解离的阴离子表面活性剂进行自顶向下蛋白质组学研究，相比对照组，已实现了检测100倍更多独特的蛋白质形式，并实现了膜蛋白的溶解，以全面表征蛋白质后转录修饰。此外，本发明的光解离的阴离子表面活性剂还适用于溶解多肽在自底向上的蛋白质组学实验中，包括细胞外基质蛋白质组学，并可作为凝胶电泳中SDS的替代品。
• US6696606B2
  申请人：——

  公开号：US6696606B2

  公开（公告）日：2004-02-24
• US7550510B2
  申请人：——

  公开号：US7550510B2

  公开（公告）日：2009-06-23
• [EN] SOLID PHASE SYNTHESIS OF ARYLRETINAMIDES<br/>[FR] SYNTHESE EN PHASE SOLIDE D'ARYLRETINAMIDES
  申请人：UNIV OHIO STATE RES FOUND

  公开号：WO2003003987A2

  公开（公告）日：2003-01-16

  A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent ; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride ; adding pyridine and a select arylamine to the resulting mixture ; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
• Solid phase synthesis of arylretinamides
  申请人：——

  公开号：US20030105164A1

  公开（公告）日：2003-06-05

  A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

  提供了一种用于制备芳基维甲酰胺的固相合成方法。该方法包括将六氯乙酮与悬浮于溶剂中的树脂结合的三苯基膦反应，以提供含有活化氯化试剂的悬浮液；将维甲酸与活化氯化试剂反应以提供维甲酰氯；向得到的混合物中加入吡啶和选择的芳基胺；并在足够时间和温度下搅拌得到的混合物，以使选择的芳基胺与维甲酰氯反应并提供芳基维甲酰胺。还提供了可以通过该方法制备的选择性芳基维甲酰胺，以及使用这些芳基维甲酰胺在癌细胞中诱导凋亡的方法。