N-alpha-邻苯二甲酰-DL-异谷氨酰胺甲酯 | 19143-28-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-alpha-邻苯二甲酰-DL-异谷氨酰胺甲酯
• 英文名称: Methyl 5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoate
• CAS: 19143-28-3
• 化学式: C₁₄H₁₄N₂O₅
• 分子量: 290.27
• InChiKey: WVZKGMCPPYUQOB-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144 °C
• 沸点：
  432.36°C (rough estimate)
• 密度：
  1.2596 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
• METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY
  申请人：West Michael D.

  公开号：US20100184033A1

  公开（公告）日：2010-07-22

  Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.
• [EN] METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY<br/>[FR] METHODES ACCELERANT L'ISOLEMENT DE NOUVELLES LIGNEES DE CELLULES A PARTIR DE CELLULES SOUCHES PLURIPOTENTES, ET CELLULES AINSI OBTENUES.
  申请人：ADVANCED CELL TECH INC

  公开号：WO2007062198A1

  公开（公告）日：2007-05-31

  [EN] This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
  [FR] L'invention porte d'une manière générale sur des méthodes de différentiation de cellules souches pluripotentes telles des souches d'embryons, des germes d'embryons ou des cellules dérivant d'embryons, pour obtenir, à partir de mélanges de cellules, des sous-populations de cellules, présentant un potentiel réduit de différenciation par rapport à celui des souches pluripotentes originales, mais capables de se propager.