5-cyclopropyl-2-phenylpyridine | 1245645-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-cyclopropyl-2-phenylpyridine
• 英文别名: 5-Cyclopropyl-2-phenylpyridine
• CAS: 1245645-30-0
• 化学式: C₁₄H₁₃N
• 分子量: 195.264
• InChiKey: DBAWNTMXTAWYKC-UHFFFAOYSA-N

物化性质

• 沸点：
  325.3±21.0 °C(Predicted)
• 密度：
  1.109±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-溴-2-苯基吡啶 、 环丙基硼酸 在 potassium phosphate tribasic heptahydrate 、 C₄₅H₅₃ClFeNO₂PPd 作用下， 以 水 、 甲苯 为溶剂， 反应 4.5h， 以86%的产率得到5-cyclopropyl-2-phenylpyridine
  参考文献：
  名称：

  Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

  摘要：

  Sphos (2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl) adduct of cyclopalladated ferrocenylimine (Ile) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.024

文献信息

• CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS
  申请人：Oryzon Genomics, S.A.

  公开号：EP2598480B1

  公开（公告）日：2019-04-24
• ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：US20200287143A1

  公开（公告）日：2020-09-10

  Provided is an organometallic compound of Chemical Formula 1: wherein. in Chemical Formula 1: X is O, S, NH, or Se; R 1 is —Si(R a )(R b )(R c ), where R a , R b , and R c are hydrogen, deuterium, or a substituted or unsubstituted C 1-10 io alkyl; R 2 , R 3 and R 4 are each independently hydrogen, deuterium, halogen, cyano, amino, a substituted or unsubstituted C 1-60 alkyl, a substituted or unsubstituted C 1-60 haloalkyl, a substituted or unsubstituted C 1-60 alkoxy, a substituted or unsubstituted C 1-60 haloalkoxy, a substituted or unsubstituted C 3-60 cycloalkyl, a substituted or unsubstituted c 2-60 alkenyl, a substituted or unsubstituted C 6-60 aryl, a substituted or unsubstituted C 6-60 aryloxy, or a substituted or unsubstituted C 2-60 heterocyclic group containing one or more heteroatoms selected from the group consisting of N, O and S; a and b are each 0 and 1, or 1 and 0, respectively; and n is 1 or 2, and an organic light emitting device including the same.
• Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle
  作者：Min Zhang、Xiuling Cui、Xiaopei Chen、Lianhui Wang、Jingya Li、Yusheng Wu、Lifen Hou、Yangjie Wu

  DOI：10.1016/j.tet.2011.11.024

  日期：2012.1

  Sphos (2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl) adduct of cyclopalladated ferrocenylimine (Ile) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated. (C) 2011 Elsevier Ltd. All rights reserved.