(E)-(S)-(+)-methyl-<2-phen-(3'methoxy)-yl> vinyl sulfoxide | 142407-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-(S)-(+)-methyl-<2-phen-(3'methoxy)-yl> vinyl sulfoxide
• CAS: 142407-30-5
• 化学式: C₁₀H₁₂O₂S
• 分子量: 196.27
• InChiKey: MFZMRHAEOYNHKA-YBJDMEARSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (E)-1-methylthio-2-(3-methoxyphenyl)ethene 反应 22.0h， 以33%的产率得到(E)-(S)-(+)-methyl-<2-phen-(3'methoxy)-yl> vinyl sulfoxide
  参考文献：
  名称：

  Microbiological and chemical methods in the asymmetric oxidation of sulfides: A comparative study for the preparation of (S)-vinyl sulfoxides

  摘要：

  The enantiogenicity of biological and chemical oxidation at the sulfur atom was studied on a series of prochiral vinyl sulfides for the preparation of sulfoxides of (S)-absolute configuration. Using either fungal cultures, Sharpless-modified reagent or chiral oxaziridine, the enantiomeric excesses varied according to the substrate's steric and/or electronic structure; the three methods were complementary.

  DOI：

  10.1016/s0957-4166(00)82296-x

文献信息

• Microbiological and chemical methods in the asymmetric oxidation of sulfides: A comparative study for the preparation of (S)-vinyl sulfoxides
  作者：Claude Rossi、Annie Fauve、Michel Madesclaire、Danielle Roche、Franklin A. Davis、R. Thimma Reddy

  DOI：10.1016/s0957-4166(00)82296-x

  日期：1992.5

  The enantiogenicity of biological and chemical oxidation at the sulfur atom was studied on a series of prochiral vinyl sulfides for the preparation of sulfoxides of (S)-absolute configuration. Using either fungal cultures, Sharpless-modified reagent or chiral oxaziridine, the enantiomeric excesses varied according to the substrate's steric and/or electronic structure; the three methods were complementary.