(2-chlorophenyl)(pyridin-3-yl)methanol | 1062153-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-chlorophenyl)(pyridin-3-yl)methanol
• 英文别名: (S)-(2-chlorophenyl)(pyridin-3-yl)methanol；(S)-(2-chlorophenyl)-pyridin-3-ylmethanol
• CAS: 1062153-60-9
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: ZWTNSRAZGILQCK-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2-氯苯基)-吡啶-3-基甲酮 在 (S)-(+)-5,5'-双[二(3,5-二叔丁基-4-甲氧基苯基)膦]-4,4'-二-1,3-苯并二氧戊环 、 polymethylhydrosiloxane 、 copper(l) chloride 、 sodium t-butanolate 、 sodium hydroxide 、 水 作用下， 以 甲苯 、 乙酸乙酯 为溶剂， 反应 1.0h， 生成 (2-chlorophenyl)(pyridin-3-yl)methanol 、 (2-chlorophenyl)(pyridin-3-yl)methanol
  参考文献：
  名称：

  Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones

  摘要：

  An efficient method for the synthesis of nonracemic diarylmethanols has been developed. The use of (R)-(-)-(DTBM-SEGPHOS)CuH effects highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones.

  DOI：

  10.1021/ol801590j

文献信息

• Asymmetric Addition of Pyridyl Aluminum Reagents to Aldehydes Catalyzed by a Titanium(IV) Catalytic System of (<i>R</i>)-H₈-BINOLate
  作者：Lijun Zhang、Bing Tu、Min Ge、Yimei Li、Liangyu Chen、Wei Wang、Shuangliu Zhou

  DOI：10.1021/acs.joc.5b01410

  日期：2015.8.21

  The asymmetric addition of pyridyl aluminum reagents to aldehydes has been successfully developed by employing a titanium(IV) catalytic system of (R)-H-8-BINOLate, which affords a series of valuable optically active diarylmethanols containing various pyridyl groups in high yields with excellent enantioselectivities of up to 98% ee.
• Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones
  作者：Ching-Tien Lee、Bruce H. Lipshutz

  DOI：10.1021/ol801590j

  日期：2008.10.2

  An efficient method for the synthesis of nonracemic diarylmethanols has been developed. The use of (R)-(-)-(DTBM-SEGPHOS)CuH effects highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones.