Mercaptobenzyl alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Mercaptobenzyl alcohol
• 英文别名: phenyl(sulfanyl)methanol
• 化学式: C₇H₈OS
• 分子量: 140.2
• InChiKey: UQDHUTAFUQLDFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-巯基苯甲醇 、 (+/-)-2-ethyl-2-(methanesulfonyloxymethyl)hexanal 、 Mercaptobenzyl alcohol 、 盐酸 在 二氯甲烷 、 sodium hydroxide 、 magnesium sulfate 作用下， 以 三乙胺 、 二乙二醇二甲醚 为溶剂， 反应 23.0h， 以to give 9.6 g of residue的产率得到2-Ethyl-2-((2-Hydroxymethylphenyl)thiomethyl)hexenal
  参考文献：
  名称：

  Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors

  摘要：

  本发明提供了新型苯并噻吩、其衍生物和类似物；包含它们的药物组合物；以及在医学中使用这些化合物和组合物的方法，特别是在哺乳动物的预防和治疗高脂血症状况，如与动脉粥样硬化或高胆固醇血症相关的情况。此外，还提供了用于联合治疗的组合物和方法，采用回肠胆汁酸转运抑制剂和EG Co-A还原酶抑制剂治疗高脂血症状况。

  公开号：

  US06268392B1

文献信息

• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• Gene delivery mediated by liposome-DNA complex with cleavable PEG surface modification
  申请人：Huang Shi-Kun

  公开号：US20050170508A1

  公开（公告）日：2005-08-04

  A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.

  描述了一种用于体内或体外递送核酸的脂质体组合物和方法。组合物中的脂质体由（i）阳离子脂质和（ii）通过可释放连接结合到亲水性聚合物的脂质组成。这些脂质体与核酸结合，用于递送到细胞。
• Liposome composition for delivery of nucleic acid
  申请人：Alza Corporation

  公开号：US20030031704A1

  公开（公告）日：2003-02-13

  A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delievery to a cell.

  描述了一种用于体内或体外递送核酸的脂质体组合物。组合物中的脂质体由（i）在生理pH下呈中性电荷，在低于生理pH值时呈正电荷的脂质和（ii）通过二硫苯基键连接到亲水聚合物的脂质组成。这些脂质体与核酸结合以递送到细胞。
• Method for treating multi-drug resistant tumors
  申请人：ALZA Corporation

  公开号：US20040161455A1

  公开（公告）日：2004-08-19

  Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.

  描述了用于向多药耐药细胞施用丝裂霉素C并减少化合物毒性的方法。在这些方法中，丝裂霉素C以前药偶联物的形式提供，其中药物通过可切割的二硫苯基连接物与疏水基团（如脂质）连接。二硫苯基连接物易受轻微硫醚解作用的影响，导致丝裂霉素C以其原始形式释放。在非还原条件下，连接物是稳定的。前药偶联物可以被包含到脂质体中，以便在体内施用，并在体内内源还原条件或外源还原剂的施用下释放丝裂霉素C。
• Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
  申请人：G.D. Searle & Co.

  公开号：US20020013476A1

  公开（公告）日：2002-01-31

  Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

  提供了新型苯并噻吩类化合物及其衍生物和类似物；含有它们的药物组合物；以及在医学中使用这些化合物和组合物的方法，特别是在哺乳动物中预防和治疗高脂血症状，如与动脉粥样硬化或高胆固醇血症相关的情况。