1,3,4,6-tetramethylpiperazine-2,5-dione | 59319-26-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3,4,6-tetramethylpiperazine-2,5-dione
• 英文别名: meso-1,3,4,6-Tetramethyl-2,5-piperazindion；racem. 1,3,4,6-Tetramethyl-2,5-piperazindion
• CAS: 59319-26-5
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: SDIOOBSMRDCPGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3,4,6-tetramethylpiperazine-2,5-dione 、 lead(IV) acetate 以9%的产率得到
  参考文献：
  名称：

  MACHIN P. J.; SAMMES P. G., J. CHEM. SOC. PERKIN TRANS., PART 1 , 1976, NO 6, 624-627

  摘要：

  DOI：
• 作为产物：
  描述：

  氨基丙酸 以40%的产率得到
  参考文献：
  名称：

  MACHIN P. J.; SAMMES P. G., J. CHEM. SOC. PERKIN TRANS., PART 1 , 1976, NO 6, 624-627

  摘要：

  DOI：

文献信息

• Theoretical and experimental vibrational property of 1,3,4,6-tetramethylpiperazine-2,5-dione
  作者：Yingying Pan、Guodong Tang、Yilan Jiang、Linxia Jiang、Ju Zhang、Renjing Lu、Lance F. Culnane、Yu Zhang、Rongqing Li

  DOI：10.1080/00387010.2016.1240086

  日期：2016.11.25

  and the crystal structure was characterized by single-crystal X-ray diffraction method, vibrational spectral measurements were obtained by Fourier transform infrared spectroscopy and Fourier transform Raman spectroscopy. The measurements agree well with the calculated geometrical structure and harmonic vibrational wavenumbers (usingab initio and density functional theory Becke’s three parameters hybrid

  摘要 合成了1,3,4,6-四甲基哌嗪-2,5-二酮，采用单晶X射线衍射法对其晶体结构进行了表征，通过傅里叶变换红外光谱和傅里叶变换拉曼光谱进行了振动光谱测量。 . 测量结果与计算的几何结构和谐波振动波数非常吻合（使用从头算和密度泛函理论 Becke 的三参数混合方法与 Lee、Yang 和 Parr 非局域函数方法以及 6-311G 和 6-311G** 基组）。
• Process for absorption of sulfur compounds from fluids using certain piperidines, piperazines, or anhydrides of monocarboxylic amino acids
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0471592A2

  公开（公告）日：1992-02-19

  Sulfur dioxide is removed from a fluid containing SO2 by employing as an absorbent for the SO2 an aqueous solution of a compound represented by Formulae I, II or III : wherein each Y is independently -(CR22)- or -(CR2)= ; each R1, R2, R5 or R6 is independently hydrogen, an alkyl group ; an hydroxyalkyl group ; an aldehyde group ; a carboxylic acid group or salt thereof ; or an alkyl group containing at least one carboxylic acid ester, a carboxylic acid or salt thereof, ether, aldehyde, ketone, or sulfoxide group ; wherein at least one of R1 and R2 and at least one of R5 and R6 is a carbonyl-containing group ; each R3 or R4 is independently hydrogen ; an alkyl group ; a hydroxyalkyl group ; an aldehyde group ; a carboxylic acid or salt group ; or an alkyl, aryl, or aralkyl group containing at least one carboxylic ester, a carboxylic acid or salt, ether, aldehyde, ketones or sulfoxide group. The absorbent solution preferably can be thermally regenerated by heating to remove SO2.

  通过使用由式 I、II 或 III 所代表的化合物的水溶液作为二氧化硫的吸收剂，从含有二氧化硫的流体中去除二氧化硫： 其中每个 Y 独立地为-(CR22)-或-(CR2)＝；每个 R1、R2、R5 或 R6 独立地为氢、烷基、羟烷基、醛基、羧酸基或其盐、或含有至少一个羧酸酯、羧酸或其盐、醚、醛、酮或亚砜基的烷基；其中 R1 和 R2 中的至少一个以及 R5 和 R6 中的至少一个是含羰基的基团；每个 R3 或 R4 独立地是氢；烷基；羟烷基；醛基；羧酸或盐基；或含有至少一个羧酸酯、羧酸或盐、醚、醛、酮或亚砜基团的烷基、芳基或芳烷基。吸收剂溶液最好可以通过加热进行热再生，以去除二氧化硫。
• YASHIMURA J.; NAKAMURA H.; MATSUNARI K., BULL. CHEM. SOC. JAP. <BCSJ-A8>, 1975, 48, NO 2, 605-609
  作者：YASHIMURA J.、 NAKAMURA H.、 MATSUNARI K.

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES
  申请人：Reiser Jochen

  公开号：US20100297139A1

  公开（公告）日：2010-11-25

  The present invention is directed to methods of treating proteinuric diseases by the administration of avβ3 integrin inhibitors.
• Methods and Compositions for the Treatment of Proteinuric Diseases
  申请人：The General Hospital Corporation

  公开号：US20160296592A1

  公开（公告）日：2016-10-13

  The present invention is directed to methods of treating proteinuric diseases by the administration of avβ3 integrin inhibitors.