6-azido-2-((tert-butoxycarbonyl)amino)hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-azido-2-((tert-butoxycarbonyl)amino)hexanoic acid
• 英文别名: Boc-Lys(ε-azide)-OH；Boc-Lys(N)-OH；6-azido-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
• 化学式: C₁₁H₂₀N₄O₄
• mdl: MFCD12547707
• 分子量: 272.304
• InChiKey: SKRPDWWWUARZIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.818
• 拓扑面积：
  90
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-azido-2-((tert-butoxycarbonyl)amino)hexanoic acid 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 azidonorleucine
  参考文献：
  名称：

  [EN] PSMA-TARGETING COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS CIBLANT PSMA ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2010108125A3

文献信息

• Compounds for Functionalizing Biomaterials
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：EP2757098A1

  公开（公告）日：2014-07-23

  The present invention provides compounds suitable for functionalizing biomaterials, in particular prosthetics and implant materials, functionalized biomaterials, and methods for synthesizing the compound. The compounds contain an anchoring group, a group for covalent binding to modified osteoblast precursor cells and a group for binding to endothelial cells or precursor cells.

  本发明提供了适用于功能化生物材料的化合物，特别是假体和植入材料，功能化生物材料以及合成该化合物的方法。该化合物包含一个锚定基团，一个用于共价结合到修饰的成骨前体细胞的基团，以及一个用于结合内皮细胞或前体细胞的基团。
• Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
  申请人：The General Hospital Corporation

  公开号：US20170362266A1

  公开（公告）日：2017-12-21

  The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.

  本申请提供了一种通过向哺乳动物投与营养物质（例如，乙酰化N-叠氮基半乳糖氨酸Ac4GalNAz）或在含有这种营养物质的生物反应器中培养器官或组织来功能化哺乳动物器官或组织的方法。本申请还提供了一种通过向哺乳动物投与营养物质（例如，乙酰化N-叠氮基半乳糖氨酸Ac4GalNAz）来选择性地功能化哺乳动物器官或组织的细胞外基质（ECM）的方法。在某些方面，本申请提供了哺乳动物器官或组织的脱细胞支架，其中脱细胞支架的细胞外基质被功能化为在生物正交化学反应中具有反应性的化学基团，例如叠氮基团。本申请还提供了根据本申请的方法制备的生物义肢网和哺乳动物器官和组织用于移植。
• PEPTIDE-COMPOUND CYCLIZATION METHOD
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20150080549A1

  公开（公告）日：2015-03-19

  An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

  本发明的目的是提供一种发现对于难以处理的靶点有效的药物的方法，这些药物通常很难被发现。本发明涉及新型的环化肽化合物的方法，以及包含这些化合物的新型肽库，以实现上述目的。
• Methods of creating and screening DNA-encoded libraries
  申请人：X-Chem, Inc.

  公开号：US11168321B2

  公开（公告）日：2021-11-09

  The present invention features a number of methods for identifying one or more compounds that bind to a biological target. The methods include synthesizing a library of compounds, wherein the compounds contain a functional moiety having one or more diversity positions. The functional moiety of the compounds is operatively linked to an initiator oligonucleotide that identifies the structure of the functional moiety.

  本发明采用多种方法鉴定与生物靶标结合的一种或多种化合物。这些方法包括合成化合物库，其中化合物含有一个或多个多样性位置的官能团。化合物的官能团与可识别官能团结构的启动子寡核苷酸操作性连接。
• Methods of generating nanoarrays and microarrays
  申请人：NAUTILUS BIOTECHNOLOGY, INC.

  公开号：US11203612B2

  公开（公告）日：2021-12-21

  The methods described herein provide a means of producing an array of spatially separated proteins. The method relies on covalently attaching each protein of the plurality of proteins to a structured nucleic acid particle (SNAP), and attaching the SNAPs to a solid support.

  本文所述方法提供了一种生产空间分离蛋白质阵列的方法。该方法将多个蛋白质中的每个蛋白质共价连接到结构化核酸颗粒（SNAP）上，并将 SNAP 连接到固体支持物上。