N-(2-phenoxyethyl)-N-propan-2-ylpropan-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-phenoxyethyl)-N-propan-2-ylpropan-2-amine
• 化学式: C₁₄H₂₃NO
• 分子量: 221.34
• InChiKey: HIBBYZLAGWDBTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Gene delivery carrier
  申请人：Massachusetts Institute of Technology

  公开号：US11041069B2

  公开（公告）日：2021-06-22

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

  本文公开了制备和利用聚（β-氨基酯）（PBAE）聚合物的方法、组合物、试剂、系统和试剂盒，这些聚合物是通过本文公开的二丙烯酸酯和胺的迈克尔加成反应合成的。不同的实施例利用内酯和内酯衍生物生成二丙烯酸酯化合物。事实证明，PBAE 聚合物是一种有效的可生物降解载体，可用于传递有机分子、无机分子、核酸、蛋白质、肽、多核苷酸、靶向剂、同位素标记的化合物、疫苗或免疫制剂等制剂。
• N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1594857A2

  公开（公告）日：2005-11-16
• GENE DELIVERY CARRIER
  申请人：Massachusetts Institute of Technology

  公开号：US20190194444A1

  公开（公告）日：2019-06-27

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
• POLYMER-LIPIDS AND COMPOSITIONS
  申请人：Massachusetts Institute of Technology

  公开号：US20200172663A1

  公开（公告）日：2020-06-04

  The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.
• [EN] NOVEL N-MONOACYLATED O-PHENYLENEDIAMINES, THEIR CONDENSED HETEROCYCLIC DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS<br/>[FR] NOUVELLES O-PHENYLENEDIAMINES N-MONOACYLEES ET LEURS DERIVES HETEROCYCLIQUES CONDENSES, ET UTILISATION DE CEUX-CI COMME AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004069133A2

  公开（公告）日：2004-08-19

  Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (I), wherein X represents N, S or O; R represents CH3-(O-CH2CH2)n- or C1-C6-alkyl, which alkyl group is monosubstituted with -CO2H, -OH, R1R2N-, pyridin-2-yl, pyrrolidin-1-yl, piperidino or morpholino; R1, R2 independently from each other denote C1-C6 alkyl; n is 1, 2, 3 or 4; and pharmaceutically acceptable salts thereof. The present invention also encompasses pharmaceutically acceptable salts or prodrugs of the compounds of formula I as well as the use of these compounds to produce medicaments.