N,N-dimethyl-3-(3-methylphenoxy)propan-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N-dimethyl-3-(3-methylphenoxy)propan-1-amine
• 化学式: C₁₂H₁₉NO
• 分子量: 193.28
• InChiKey: MZIKMXLBXAMURF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] THERAPEUTIC USE OF IMIDAZOPYRIDINE DERIVATIVES<br/>[FR] UTILISATION THÉRAPEUTIQUE DE DÉRIVÉS D'IMIDAZOPYRIDINE
  申请人：SANOFI SA

  公开号：WO2013102860A1

  公开（公告）日：2013-07-11

  The invention relates to the use of compounds corresponding to formula (I) in which R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of the formulae (A), (B) and (C) in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached, or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.

  该发明涉及使用符合式(I)的化合物，其中R2和R3共同形成与它们附着的苯环的碳原子一起，对应于式(A)、(B)和(C)之一的6元氮杂环，其中波浪线代表R2和R3附着的苯环，或其药学上可接受的盐，用于制备治疗膀胱癌的药物。
• [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof
  申请人：Masuda Akira

  公开号：US20070010515A1

  公开（公告）日：2007-01-11

  Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.

  这是一种通式为(1)的[1,2,4]三唑并[1,5-a]嘧啶衍生物的小说，其中(1)是其前药或其药学上可接受的盐，具有抗原呈递抑制活性，可用作预防和/或治疗器官/骨髓移植、自身免疫性疾病、过敏性疾病和/或炎症性疾病的免疫排斥和/或移植物抗宿主反应的预防和/或治疗剂，同时也可用作抗癌药物或用于移植器官/移植骨髓的免疫耐受诱导剂。
• THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF
  申请人：Adachi Kunitomo

  公开号：US20100041643A1

  公开（公告）日：2010-02-18

  [Solving means] A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. [Effect]Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.

  【解决方法】以下式(I)的噻唑三唑二氮杂环化合物，以其为活性成分的药物制剂，以及噻唑三唑二氮杂环化合物的生产中间体和生产方法。 【效果】由于该化合物对T细胞上的CD28共刺激信号具有抑制作用，因此它对于预防或抑制器官或骨髓移植等排斥反应，以及预防或治疗自身免疫性疾病或过敏疾病非常有用。
• 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF
  申请人：NAGATO Satoshi

  公开号：US20090275751A1

  公开（公告）日：2009-11-05

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新型化合物，具有优异的AMPA受体抑制作用和/或kainate抑制作用。该化合物的化学式如下，其盐或水合物：在该式中，Q表示NH、O或S；R1、R2、R3、R4和R5相同或不同，且每个表示氢原子、卤素原子、C1-6烷基或由式—X-A表示的基团（其中X表示单键、可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基或5-至14元杂环芳香族基等）。
• Organic Compounds
  申请人：Shaw Duncan

  公开号：US20100210641A1

  公开（公告）日：2010-08-19

  Compounds of formula I: in free or salt or solvate form, where R 1 , R 2 , R 3 and R 20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.

  式I的化合物：以自由或盐或溶剂形式存在，其中R1，R2，R3和R20具有规范中指定的含义，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。还描述了含有这些化合物的制药组合物和制备这些化合物的方法。这些化合物对于治疗炎症或阻塞性呼吸道疾病，如肺动脉高压，肺纤维化，肝纤维化，癌症，肌肉疾病，如肌肉萎缩和肌肉营养不良，以及全身性骨骼疾病，如骨质疏松症非常有用。