(R)-2′,6′-dimethyltyrosine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2′,6′-dimethyltyrosine
• 英文别名: (R)-2,6-dimethyltyrosine；(2R)-2-azaniumyl-3-(4-hydroxy-2,6-dimethylphenyl)propanoate
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: LSNDLIKCFHLFKO-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以99%的产率得到(R)-N-(2-benzoyl-4-chlorophenyl)-2-((1-phenylethyl)amino)acetamide
  参考文献：
  名称：

  （S）-和（R）-α-（苯基）乙胺衍生的NH型配体的设计与合成及其在α-氨基酸化学拆分中的应用†

  摘要：

  这项工作提出了解析α-氨基酸的第一种化学方法，具有以下优点：（1）专门设计的拆分试剂衍生自最便宜的手性助剂α-（苯基）乙胺，可以回收和再利用，使整个过程的成本结构非常有吸引力；（2）省时的两步法可以在操作方便的条件下进行，产量几乎是定量的；（3）该方法可以很容易地适应大规模使用。

  DOI：

  10.1039/c4ob00669k

文献信息

• [EN] BRANCHED PEPTIDES FOR ENZYMATIC ASSEMBLY AND MITOCHONDRIA DRUG DELIVERY<br/>[FR] PEPTIDES RAMIFIÉS POUR ASSEMBLAGE ENZYMATIQUE ET ADMINISTRATION DE MÉDICAMENT À DES MITOCHONDRIES
  申请人：UNIV BRANDEIS

  公开号：WO2019055988A1

  公开（公告）日：2019-03-21

  The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.

  本发明涉及一种分支肽，包括第一肽链和第二肽链，其中第二肽链的C端氨基酸与第一肽链的氨基酸残基的侧链共价连接，第一肽链包括多个芳香族氨基酸和可选的连接到第一肽链氨基端的芳香基团；第二肽链包括多个亲水性氨基酸和一个酶切位点。本发明还揭示了含有分支肽和一种或多种治疗剂的药物组合物，其中分支肽在水介质中形成胶束结构。本发明还描述了使用药物组合物传递治疗剂和治疗各种疾病的方法。
• Branched peptides for enzymatic assembly and mitochondria drug delivery
  申请人：BRANDEIS UNIVERSITY

  公开号：US11191724B2

  公开（公告）日：2021-12-07

  The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.

  本发明涉及一种支链肽，它包括第一肽链和第二肽链，第二肽链的C-末端氨基酸与第一肽链氨基酸残基的侧链共价连接，其中第一肽链包括多个芳香族氨基酸，可选地，芳香族基团与第一肽链的氨基末端连接；第二肽链包括多个亲水性氨基酸和酶裂解位点。公开了在水介质中含有支链肽和一种或多种治疗剂的药物组合物，其中支链肽在水介质中形成胶束结构。还描述了使用药物组合物递送治疗剂和治疗各种疾病的方法。
• BRANCHED PEPTIDES FOR ENZYMATIC ASSEMBLY AND MITOCHONDRIA DRUG DELIVERY
  申请人：BRANDEIS UNIVERSITY

  公开号：US20200281854A1

  公开（公告）日：2020-09-10

  The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.
• US4797470A
  申请人：——

  公开号：US4797470A

  公开（公告）日：1989-01-10