2,3-dihydro-6-(1,1-dimethylethyl)benzo[b]-1,4-dithiin | 127634-82-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-dihydro-6-(1,1-dimethylethyl)benzo[b]-1,4-dithiin
• 英文别名: 6-Tert-butyl-2,3-dihydro-1,4-benzodithiine
• CAS: 127634-82-6
• 化学式: C₁₂H₁₆S₂
• 分子量: 224.391
• InChiKey: SJRXXRCOOOKCDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-6-(1,1-dimethylethyl)benzo[b]-1,4-dithiin 在 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以62%的产率得到5-tert-Butyl-2-methyl-benzo[1,3]dithiole
  参考文献：
  名称：

  Satoh, James Y.; Kuroda, Chiaki; Yamada, Takashi, Chemistry Letters, 1989, p. 2081 - 2082

  摘要：

  DOI：
• 作为产物：
  描述：

  8-tert-Butyl-1,4-dithia-spiro[4.5]decane 在 溴 作用下， 以 氯仿 为溶剂， 反应 1.66h， 生成 2,3-dihydro-6-(1,1-dimethylethyl)benzo[b]-1,4-dithiin
  参考文献：
  名称：

  乙二醛S，S-缩醛的反应性-3.环己酮衍生物中的环芳构化：1,4-苯并二胺的新颖合成

  摘要：

  据报道，通过简单地同时进行六元环的芳构化和五元含硫环的扩容，环己酮和取代的环己酮的乙二胺S，S-乙缩醛衍生物可以快速，平稳地转化为1,4-苯并二噻吩。在室温下用无水氯仿中的溴处理。这种转化代表了迄今为止报道的第一种合成方法，导致苯环上的1，4-苯并二胺（2）被各种取代。后者的现成可用性使得1,4-苯并二胺体系本身被视为吸引人的中间体，可在硫置换或除去后获得在通常的亲电取代条件下无法制备的芳族化合物。

  DOI：

  10.1016/s0040-4020(01)86455-3

文献信息

• Mo‐Based Oxidizers as Powerful Tools for the Synthesis of Thia‐ and Selenaheterocycles
  作者：Peter Franzmann、Sebastian B. Beil、Dieter Schollmeyer、Siegfried R. Waldvogel

  DOI：10.1002/chem.201805938

  日期：2019.2.6

  A highly efficient synthetic protocol for the synthesis of thia‐ and selenaheterocycles has been developed. By employing a MoCl5‐mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide

  已经开发了用于合成噻吩和亚硒杂环的高效合成方案。通过使用MoCl 5介导的分子内脱氢偶联反应，可以分离出多种结构基序，产率最高可达94％。几个不稳定的部分（如卤化物和叔烷基）可以忍受亲电子键的转变。由于使用了二硫化物或二硒化物前体，因此获得了很高的原子效率。
• C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF
  申请人：JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20160222047A1

  公开（公告）日：2016-08-04

  C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.

  本文描述了C-芳基葡萄糖苷衍生物，其制备方法以及医药应用。具体而言，描述了由式I表示的化合物，以及该化合物的互变异构体、对映体、非对映体、拉卡酯和药学上可接受的盐，其制备方法，含有该化合物的药物组合物以及其应用。式(I)的化合物可用作治疗剂，特别是作为钠依赖葡萄糖共转运蛋白（SGLT）抑制剂。
• PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH
  申请人：Lin Linus S.

  公开号：US20110144056A1

  公开（公告）日：2011-06-16

  The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease

  本发明涉及某些咪唑衍生物，它们可用作脂肪酸酰胺水解酶（FAAH）的抑制剂。本发明还涉及包含这些化合物作为活性成分的制药组合物，以及这些化合物及其制剂在治疗某些疾病中的应用，包括骨关节炎、类风湿性关节炎、糖尿病神经病变、带状疱疹后神经痛、骨骼肌疼痛和纤维肌痛，以及急性疼痛、偏头痛、睡眠障碍、阿尔茨海默病和帕金森病。
• IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH
  申请人：Lin Linus S.

  公开号：US20110269769A1

  公开（公告）日：2011-11-03

  The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.

  本发明涉及某些咪唑衍生物，其作为脂肪酸酰胺水解酶（FAAH）抑制剂而有用。本发明还涉及包含这些化合物作为活性成分的制药配方以及这些化合物及其配方在治疗某些疾病中的使用，包括骨关节炎、类风湿性关节炎、糖尿病神经病、带状疱疹后神经痛、骨骼肌疼痛和纤维肌痛，以及急性疼痛、偏头痛、睡眠障碍、阿尔茨海默病和帕金森病。
• C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
  申请人：YOUNGENE THERAPEUTICS CO., LTD

  公开号：US10011627B2

  公开（公告）日：2018-07-03

  C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.

  描述了 C-芳基葡萄糖苷衍生物、其制备方法及其医学应用。具体地说，描述了式 I 所代表的化合物、化合物的同分异构体、对映体、非对映体、外消旋体和药学上可接受的盐、其制备方法、含有化合物的药物组合物及其应用。式（I）化合物可用作治疗剂，特别是钠依赖性葡萄糖转运蛋白（SGLT）抑制剂。