4-(Trimethylammonio)but-2-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(Trimethylammonio)but-2-enoic acid
• 英文别名: [(E)-3-carboxyprop-2-enyl]-trimethylazanium
• 化学式: C7H14NO2+
• 分子量: 144.19
• InChiKey: GUYHPGUANSLONG-SNAWJCMRSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROCESS FOR THE PRODUCTION OF CARNITINE FROM BETA-LACTONES
  申请人：Hanselmann Paul

  公开号：US20120022288A1

  公开（公告）日：2012-01-26

  The invention relates to a method for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

  这项发明涉及一种生产左旋肉碱的方法，其中一种β-内酯，即4-(卤甲基)氧杂环戊烷-2-酮，通过三甲胺（TMA）转化为肉碱，其中在与三甲胺接触之前，β-内酯不经过碱性水解步骤。该发明还涉及一种具有独特杂质谱的肉碱。
• PROCESS FOR THE PRODUCTION OF CARNITINE BY CYCLOADDITION
  申请人：Hanselmann Paul

  公开号：US20120022275A1

  公开（公告）日：2012-01-26

  The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH 2 —CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

  这项发明涉及一种生产左旋肉碱的方法，其中通过醛X—CH2—CHO与酮烯进行[2+2]环加成反应，在手性催化剂的存在下获得手性β-内酯肉碱前体，其中X选自Cl、Br、I和三甲胺。
• [EN] A PROCESS FOR THE PRODUCTION OF CARNITINE FROM ß-LACTONES<br/>[FR] PROCÉDÉ DE PRODUCTION DE CARNITINE À PARTIR DE ?-LACTONES
  申请人：LONZA AG

  公开号：WO2012010297A1

  公开（公告）日：2012-01-26

  The invention relates to a method for the production of L-carnitine, wherein a β- lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

  该发明涉及一种生产L-肉碱的方法，其中一种β-内酯，即4-(卤甲基)噁二酮，通过三甲胺(TMA)转化为肉碱，其中在与三甲胺接触之前，β-内酯未经过基础水解步骤。该发明还涉及一种具有独特杂质谱的肉碱。
• [EN] A PROCESS FOR THE PRODUCTION OF CARNITINE<br/>[FR] PROCÉDÉ DE PRODUCTION DE CARNITINE
  申请人：LONZA AG

  公开号：WO2012010296A1

  公开（公告）日：2012-01-26

  The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X-CH2-CHO, wherein X is selected from CI, Br, I and trimethylamine, in the presence of a chiral catalyst.

  该发明涉及一种生产L-肉碱的方法，其中通过在手性催化剂存在下，将酮与醛X-CH2-CHO（其中X选择自CI、Br、I和三甲胺）进行[2+2]环加成反应，从而得到手性β-内酯肉碱前体。
• BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS
  申请人：Baynes Brian M.

  公开号：US20120301950A1

  公开（公告）日：2012-11-29

  Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

  本文提供了在微生物中生产双官能基烷烃的方法。同时还提供了编码这种酶的核酸和酶，与从碳水化合物饲料中生产双官能基烷烃相关。本发明还提供了重组微生物和代谢途径，用于生产双官能基烷烃。