(4E)-2-Oxohexenoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: (4E)-2-Oxohexenoic acid
• 英文别名: (E)-2-oxohex-4-enoic acid
• 化学式: C₆H₈O₃
• 分子量: 128.13
• InChiKey: XGNKMQBCAVIQOR-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2Z,4E)-2-(Toluene-4-sulfonyloxy)-hexa-2,4-dienoic acid 、 sodium hydroxide 生成 (4E)-2-Oxohexenoic acid
  参考文献：
  名称：

  TANAKA KIYOSHI; NAKAI TAKESHI; ISHIKAWA NOBUO, TETRAHEDRON LETT., 1978, NO 48, 4809-4810

  摘要：

  DOI：

文献信息

• Quinazoline Derivatives For Inhibiting Cancer Cell Growth And Method For The Preparation Thereof
  申请人：Ham Young Jin

  公开号：US20080009509A1

  公开（公告）日：2008-01-10

  The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof for inhibiting the growth of cancer cells, a method for the preparation thereof and a pharmaceutical composition comprising same as an active ingredient.

  本发明涉及一种新型的喹唑啉衍生物及其药学上可接受的盐，用于抑制癌细胞的生长，其制备方法以及包含其作为活性成分的制药组合物。
• Continuous hydroformylation process
  申请人：DSM N.V.

  公开号：EP1249439A1

  公开（公告）日：2002-10-16

  A continuous hydroformylation process for forming an aldehyde comprising: A) reacting an olefinically unsaturated compound containing from 6 to 30 carbon atoms, carbon monoxide, hydrogen, and a rhodium-bisphosphite ligand complex catalyst to form a reaction mixture B) evaporating at least a portion of said liquid reaction mixture to isolate aldehyde product C) recycling the catalyst after the evaporation, wherein said evaporation is accomplished in a vacuum evaporator with a short mean residence time and a moderate thermal exposure of the liquid reaction mixture in the evaporator.

  一种用于形成醛的连续加氢甲酰化工艺，包括 A) 使含有 6 至 30 个碳原子的烯烃不饱和化合物、一氧化碳、氢和二磷酸铑配位体络合物催化剂反应，形成反应混合物 B) 蒸发所述液态反应混合物的至少一部分，以分离出醛产物 C) 蒸发后回收催化剂、 其中，所述蒸发在真空蒸发器中完成，平均停留时间短，液体反应混合物在蒸发器中的热暴露适中。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• CONTINUOUS HYDROFORMYLATION PROCESS
  申请人：DSM IP Assets B.V.

  公开号：EP1392633A1

  公开（公告）日：2004-03-03
• QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP1844022A1

  公开（公告）日：2007-10-17