N-乙氧基甲基丙烯酰胺 | 13036-41-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-乙氧基甲基丙烯酰胺
• 英文名称: N-(Ethoxy-methyl)-acrylsaeureamid
• 英文别名: N-(ethoxymethyl)acrylamide；N-(ethoxymethyl)prop-2-enamide
• CAS: 13036-41-4
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: LSWADWIFYOAQRZ-UHFFFAOYSA-N

物化性质

• 熔点：
  6-9 °C
• 沸点：
  94-96 °C(Press: 0.1 Torr)
• 密度：
  1.0192 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 乙醇 、 丙烯酰胺 生成 N-乙氧基甲基丙烯酰胺
  参考文献：
  名称：

  N-(Alkoxymethyl)acrylamides

  摘要：

  DOI：

  10.1021/jo01047a044

文献信息

• Proline ester and preparation containing the same for percutaneous administration
  申请人：Furuishi Takayuki

  公开号：US20050288232A1

  公开（公告）日：2005-12-29

  A proline ester represented by the following formula (I): wherein R 1 represents a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, or a lower alkoxy-lower alkoxy-lower alkyl group or a pharmaceutically acceptable salt thereof. The proline ester (I) of the present invention and a pharmaceutically acceptable salt thereof are useful as a prodrug of enalaprilat, which is a medicine useful for preventing or treating circulatory diseases such as hypertension, cardiac diseases (e.g., cardiac hypertrophy, cardiac failure, and myocardial infarct), nephritis, and apoplexy. Thus, a drug containing the ester or a salt thereof is preferably formulated to a percutaneous preparation, particularly a patch, from the viewpoint of medicinal activity and use.

  以下是翻译结果： 一种由以下式子(I)所表示的脯氨酸酯： 其中R1代表羟基-低烷基基团、低烷氧基-低烷基基团或低烷氧基-低烷氧基-低烷基基团，或其药学上可接受的盐。本发明的脯氨酸酯(I)及其药学上可接受的盐可作为依那普利酸的前药，该药物可用于预防或治疗循环系统疾病，如高血压、心脏疾病（如心肌肥大、心力衰竭和心肌梗死）、肾炎和中风。因此，含有该酯或其盐的药物最好从药效和用途的角度来看，制成经皮制剂，特别是贴片。
• Percutaneous absorption preparation
  申请人：Suzuki Yasuyuki

  公开号：US20090264521A1

  公开（公告）日：2009-10-22

  Percutaneous absorption preparations which make it possible to absorb compounds having a melatonin receptor agonist activity via a convenient administration system, have favorable blood-drug-concentration-time profile and can exert a therapeutic effect on a disease caused by a decrease in secretion of melatonin at night.

  经皮吸收制剂可以通过方便的给药系统吸收具有褪黑素受体激动剂活性的化合物，具有良好的血药浓度时间曲线，并可以对由于夜间褪黑素分泌减少而引起的疾病产生治疗效果。
• INK FOR INKJET RECORDING AND IMAGE FORMING METHOD
  申请人：SHIBATA Naoya

  公开号：US20110069122A1

  公开（公告）日：2011-03-24

  There is provided is an ink for inkjet recording, comprising: a pigment coated with a water-insoluble resin including a structural unit represented by the following formula (1) and a structural unit having an ionic group; a nitrogen-containing organic solvent; resin particles; and water, wherein a mass ratio [nitrogen-containing organic solvent/resin particles] is from 2.0 to 6.0: wherein, in formula (1), R 1 represents a hydrogen atom, a methyl group, or a halogen atom; L 1 represents *—COO—, —OCO—, *—CONR 2 —, *—O—, or a substituted or unsubstituted phenylene group, wherein “*—” represents a bond linking to the main chain; R 2 represents a hydrogen atom, or an alkyl group having 1 to 10 carbon atoms; and L 2 represents a single bond or a divalent linking group having 1 to 30 carbon atoms, and a image forming method.

  提供了一种用于喷墨记录的油墨，包括：被涂覆有水不溶性树脂的颜料，所述水不溶性树脂包括由以下公式（1）表示的结构单元和具有离子基的结构单元；含氮有机溶剂；树脂粒子；和水，其中质量比【含氮有机溶剂/树脂粒子】为2.0至6.0：其中，在公式（1）中，R1表示氢原子、甲基基团或卤素原子；L1表示*—COO—、—OCO—、*—CONR2—、*—O—或取代或未取代的苯基烷基，其中“*—”表示与主链连接的键；R2表示氢原子或具有1至10个碳原子的烷基基团；L2表示单键或具有1至30个碳原子的二价连接基团，以及一种图像形成方法。
• PERCUTANEOUS ABSORPTION PREPARATIONS
  申请人：SUZUKI Yasuyuki

  公开号：US20120309823A1

  公开（公告）日：2012-12-06

  Percutaneous absorption preparations which make it possible to absorb compounds having a melatonin receptor agonist activity via a convenient administration system, have favorable blood-drug-concentration-time profile and can exert a therapeutic effect on a disease caused by a decrease in secretion of melatonin at night.

  经皮吸收制剂使得通过便捷的给药系统吸收具有褪黑素受体激动剂活性的化合物成为可能，具有良好的血药浓度-时间曲线，并且可以对由夜间褪黑素分泌减少引起的疾病产生治疗效果。
• POLARIZED FILM, OPTICAL FILM, AND IMAGE DISPLAY DEVICE
  申请人：NITTO DENKO CORPORATION

  公开号：US20150049380A1

  公开（公告）日：2015-02-19

  A polarizing film, comprising a polarizer; transparent protective films with a water-vapor permeability of 150 g/m2/24 hours or less provided on both sides of the polarizer; and adhesive layers each interposed between the polarizer and one of the transparent protective films, wherein the adhesive layers are formed by applying an active energy ray to an active energy ray-curable adhesive composition containing a radically polymerizable compound, and the transparent protective films are bonded to the polarizer with the adhesive layers.

  一种偏光膜，包括偏光器；透明保护膜，在偏光器的两侧提供，其水汽渗透率为每平方米每24小时150克或以下；以及粘合层，每个粘合层夹在偏光器和一个透明保护膜之间，其中粘合层是通过将活性能量射线应用于含有自由基聚合化合物的活性能量射线可固化粘合剂组成的，透明保护膜与偏光器通过粘合层粘合在一起。