4-Hexyl-decanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Hexyl-decanoic acid
• 英文别名: 4-hexyldecanoic acid
• 化学式: C₁₆H₃₂O₂
• 分子量: 256.42
• InChiKey: AZHXWUMGGSQNGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Hexyl-decanoic acid 、 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以196 mg的产率得到
  参考文献：
  名称：

  可电离脂质化合物

  摘要：

  本发明提供了一类新型可电离脂质化合物，或其药学上可接受的盐、同位素变体、互变异构体或立体异构体，其药物组合物，及其在制备预防性或治疗性核酸疫苗中的应用。

  公开号：

  CN117820149A

文献信息

• Bicyclic peptide ligands and uses thereof
  申请人：BicycleTx Limited

  公开号：US10857196B2

  公开（公告）日：2020-12-08

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF
  申请人：Georgia Tech Research Corporation

  公开号：EP2279417B1

  公开（公告）日：2016-07-20
• AMINO ACID-, PEPTIDE- AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20170165290A1

  公开（公告）日：2017-06-15

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , Z, W, Y, and Z are as defined herein.
• PEPTIDOMIMETIC AGENTS, SYNTHESIS AND USES THEREOF
  申请人：THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH

  公开号：US20200354404A1

  公开（公告）日：2020-11-12

  Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.
• BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF
  申请人：BicycleRD Limited

  公开号：US20210079045A1

  公开（公告）日：2021-03-18

  The present invention provides compounds, compositions thereof, and methods of using the same.