2,6-Dimethyl-hexadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-Dimethyl-hexadecanoic acid
• 英文别名: 2,6-dimethylhexadecanoic acid
• 化学式: C₁₈H₃₆O₂
• 分子量: 284.5
• InChiKey: AIJKUSCCAPFTGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pharmaceutical magnetic nano-particle composition
  申请人：UNIVERSITÄTSKLINIKUM ERLANGEN

  公开号：EP2508171A1

  公开（公告）日：2012-10-10

  The invention relates to a pharmaceutical composition comprising magnetic nano-particles for magnetic targeting of drugs and imaging agents. The invention further relates to the use of said pharmaceutical composition as a drug carrier, for use as an imaging agent, for use as a medicament and specifically for use in cancer treatment by magnetic drug targeting using an external magnetic field. The present invention also relates to a method for manufacturing said pharmaceutical composition and a method for guiding and accumulating said pharmaceutical composition to a target tissue contained in a subject.

  本发明涉及一种药物组合物，其中包含用于药物和成像剂磁性靶向的磁性纳米颗粒。本发明还涉及将所述药物组合物用作药物载体、用作成像剂、用作药物，特别是用于利用外部磁场进行磁性药物靶向治疗癌症。本发明还涉及一种制造所述药物组合物的方法，以及一种将所述药物组合物引导和积聚到受试者所含靶组织的方法。
• METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF
  申请人：Georgia Tech Research Corporation

  公开号：EP2279417A1

  公开（公告）日：2011-02-02
• LONG CHAIN FATTY ACID FORMULATIONS AND THEIR USE IN INHIBITING SALMONELLA INFECTION
  申请人：CORNELL UNIVERSITY

  公开号：US20200330420A1

  公开（公告）日：2020-10-22

  A method for inhibiting or preventing Salmonella invasion of the intestinal epithelium in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, wherein the fatty acid is more particularly an unsaturated fatty acid containing 1-4 carbon-carbon double bonds and/or 1 or 2 carbon-carbon triple bonds, or the fatty acid is more particularly a cis-unsaturated fatty acid, or the fatty acid is more particularly a cis-2-unsaturated fatty acid having the formula: wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms.
• [EN] METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF<br/>[FR] BIOMARQUEURS MÉTABOLIQUES POUR LE CANCER DES OVAIRES ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：GEORGIA TECH RES INST

  公开号：WO2009151967A1

  公开（公告）日：2009-12-17

  Panels of serum metabolic biomarkers and methods of their use in detecting and diagnosing cancer, especially ovarian cancer, are disclosed. The metabolic biomarker panels include 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 50, 75, 100, 150, or more metabolites. Supervised classification methods, such as trained support vector machines (SVMs) are used to determine whether the levels of metabolic biomarkers in a subject are indicative of the presence of cancer. The disclosed biomarkers and methods preferably allow a diagnosis of cancer with an accuracy, a specificity, and/or a sensitivity of at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99%.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING VIBRIO INFECTION<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION D'UNE INFECTION PAR VIBRIO
  申请人：UNIV CORNELL

  公开号：WO2021202632A2

  公开（公告）日：2021-10-07

  Disclosed herein is a method for inhibiting or preventing Vibrio cholera toxin production in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, such as an unsaturated fatty acid such as a cis-2-unsaturated fatty acid, such as a fatty acid having the formula (1) wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms. Also disclosed herein is a method for treating or preventing a Vibrio infection comprising administering to a subject in need of treatment an effective amount of a genetically engineered bacterium, wherein the genetically engineered bacterium comprises an exogenous nucleic acid encoding an enzyme that produces a diffusible signal factor (DSF) by introducing a cis-2 double bond to a fatty acid.